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Ncam1 Gene Detail
 Symbol
Name
ID
Ncam1
neural cell adhesion molecule 1
MGI:97281

Nomenclature History
STS D9Mit22,D9Mit26,D9Mit94,D9Mit98,D9Nds6
Synonyms CD56, E-NCAM, NCAM-1, NCAM-120, NCAM-140, NCAM-180
Genetic Map
Chromosome 9
28.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 31)

Sequence Map
Chr9:49310257-49606834 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ncam1 ± 2 cM)
Protein SuperFamily: cell adhesion molecule, NCAM/Fasciclin-2 types
TreeFam: TF326195
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000039542 Ensembl Gene Model | MGI Sequence Detail 296578 C57BL/6J ± Kb
transcript NM_001081445 RefSeq | MGI Sequence Detail 6192 C57BL/6
polypeptide P13595 UniProt | EBI | MGI Sequence Detail 1115 Not Applicable
For the selected sequences
All sequences(56)
Alleles
and
phenotypes 		All alleles(16) : Targeted, knock-out(4) Targeted, other(2) Gene trapped(10)
Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and morphological and functional defects of neuromuscular junctions.
Polymorphisms All PCR and RFLP(9) : PCR(5) RFLP(4) SNPs within 2kb(1692 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, cell surface receptor linked signal transduction...
Component anchored to membrane, axon...
Function heparin binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (181 records)
Data Summary: Assays (36)    Results (247)    Tissues (116)    Images (71)
Theiler Stages: 4,5,8,9,10,11,12,13,14,15,16,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 8   63
      RT-PCR 4   27
      RNA in situ 5   71
      Immunohistochemistry 16   82
      Nuclease S1 2   3
      Northern blot 1   1
cDNA source data(37)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(81) Genomic(28) cDNA(44) Primer pair(6) Other(3) Antibodies(19)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000039542
Consensus CDS Project CCDS40617.1, CCDS40618.1
PDB 2NCM, 3NCM
DFCI TC1579658, TC1591322, TC1598634, TC1605247, TC1625601, TC1640840, TC1644052
NIA Mouse Gene Index U030833
Entrez Gene 17967
International Mouse Knockout Project Status Ncam1
Protein
domains
InterPro ID Description
IPR003598 Immunoglobulin subtype 2
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like
IPR008957 Fibronectin, type III-like fold
IPR009138 Neural cell adhesion
IPR013098 Immunoglobulin I-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:37744 Rougon G et al., "Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide." EMBO J 1982;1(10):1239-44
(Latest) J:155440 Boutin C et al., "NCAM expression induces neurogenesis in vivo." Eur J Neurosci 2009 Oct;30(7):1209-18
All references(320)
Other
accession IDs 		MGD-MRK-12786
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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