Symbol
Name
ID
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Synonyms
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c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, thrombopoietin receptor, TPO-R
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(36)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(3)
Chemically induced(1)
| Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(81 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (10 records)
Data Summary:
Assays (8)
Results (49)
Tissues (37)
Images (1)
Theiler Stages: 9,10,12,14,16,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
5 |
|
25 |
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Nuclease S1 |
2 |
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4 |
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Northern blot |
1 |
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20 |
cDNA source data(14)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(25)
Genomic(2)
cDNA(14)
Primer pair(6)
Other(3)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR003528 |
Long hematopoietin receptor, single chain, conserved site |
| IPR003961 |
Fibronectin, type III |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR015152 |
Erythropoietin receptor, ligand binding |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:9693
Wendling F et al.,
"Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus."
Blood 1989 Apr;73(5):1161-7
(Latest)
J:154615
Looney MR et al.,
"Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury."
J Clin Invest 2009 Nov;119(11):3450-61
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All references(71)
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Other
accession IDs
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MGD-MRK-12409, MGI:2678710
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Analysis Tools
MGI BioMart
