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Mmp2 Gene Detail
 Symbol
Name
ID
Mmp2
matrix metallopeptidase 2
MGI:97009


Nomenclature History
Synonyms 72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2
Genetic Map
Chromosome 8
44.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr8:95351227-95377316 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mmp2 ± 2 cM)
Protein SuperFamily: gelatinase A
TreeFam: TF315428
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000031740 Ensembl Gene Model | MGI Sequence Detail 26090 C57BL/6J ± Kb
transcript NM_008610 RefSeq | MGI Sequence Detail 3070 C57BL/6
polypeptide P33434 UniProt | EBI | MGI Sequence Detail 662 Not Applicable
For the selected sequences
All sequences(65)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.
Polymorphisms RFLP(1) SNPs within 2kb(246 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process blood vessel maturation, bone trabecula formation...
Component extracellular matrix, extracellular region...
Function calcium ion binding, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (51 records)
Data Summary: Assays (8)    Results (23)    Tissues (13)    Images (3)
Theiler Stages: 17,19,20,21,22,23,28
  Assay Type Assays   Results
      Western blot 1   3
      RT-PCR 5   14
      RNA in situ 1   2
      Immunohistochemistry 1   4
cDNA source data(171)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(177) cDNA(171) Primer pair(4) Other(2) Antibodies(2)
Microarray probesets(2)
Other database
links
EC 3.4.24.24
Ensembl Gene Model ENSMUSG00000031740
DoTS DT.111178769, DT.495126, DT.91351894
Consensus CDS Project CCDS22523.1
UniGene 29564
DFCI TC1571950
NIA Mouse Gene Index U009639
Entrez Gene 17390
International Mouse Knockout Project Status Mmp2
Protein
domains
InterPro ID Description
IPR000562 Type II fibronectin, collagen-binding
IPR000585 Hemopexin/matrixin
IPR001818 Peptidase M10A/M12B, matrixin/adamalysin
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidases
IPR013806 Kringle-like fold
IPR018486 Hemopexin/matrixin, conserved site
IPR018487 Hemopexin/matrixin, repeat
Graphical View of Protein Domain Structure
References
(Earliest) J:218 Bennett D, "Brain hernia, a new recessive mutation in the mouse" J Hered 1959;50():265-8
(Latest) J:155674 Munoz M et al., "Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17." J Exp Med 2009 Dec 21;206(13):3047-59
All references(151)
Other
accession IDs
MGD-MRK-12279, MGD-MRK-2013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory