Symbol
Name
ID
|
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Synonyms
|
Emt, Tcsk, Tsk
|
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(33)
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Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(2)
Targeted, other(1)
| Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(270 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
|
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Expression
|
cDNA source data(65)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(72)
Genomic(2)
cDNA(69)
Primer pair(1)
Microarray probesets(3)
|
Other database
links
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| EC |
2.7.10.2 |
| Ensembl Gene Model |
ENSMUSG00000020395 |
| DoTS |
DT.40146282, DT.91302218, DT.91331863, DT.91336037, DT.91337453, DT.94155250 |
| Consensus CDS Project |
CCDS24575.2 |
| UniGene |
339927 |
| PDB |
1AWJ, 1LUI, 1LUK, 1LUM, 1LUN, 2ETZ, 2EU0, 2K79, 2K7A, 2RN8, 2RNA |
| DFCI |
TC1577779, TC1599238 |
| NIA Mouse Gene Index |
U032699 |
| Entrez Gene |
16428 |
| VEGA Gene Model |
OTTMUSG00000005493 |
| International Mouse Knockout Project Status |
Itk |
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:33070
Bernards A et al.,
"The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator."
EMBO J 1990 Jul;9(7):2279-87
(Latest)
J:153810
Gomez-Rodriguez J et al.,
"Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase."
Immunity 2009 Oct 16;31(4):587-97
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All references(56)
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Other
accession IDs
|
MGD-MRK-11504, MGD-MRK-14937
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Analysis Tools
MGI BioMart
