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Il1rn Gene Detail
 Symbol
Name
ID
Il1rn
interleukin 1 receptor antagonist
MGI:96547

Nomenclature History
STS D2Mit60
Synonyms F630041P17Rik, IL-1ra
Genetic Map
Chromosome 2
10.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr2:24192373-24207014 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Il1rn ± 2 cM)
Protein SuperFamily: interleukin-1
TreeFam: TF300203
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000011966 VEGA Gene Model | MGI Sequence Detail 14642 C57BL/6J ± Kb
transcript NM_001039701 RefSeq | MGI Sequence Detail 2480 C57BL/6
polypeptide P25085 UniProt | EBI | MGI Sequence Detail 178 Not Applicable
For the selected sequences
All sequences(49)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(4)
Polymorphisms All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(115 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process insulin secretion, lipid metabolic process...
Component cytoplasm, extracellular region...
Function interleukin-1 receptor antagonist activity, receptor activity...
External Resources: FuncBase
Expression cDNA source data(24)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(31) Genomic(4) cDNA(24) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000026981
DoTS DT.101372120, DT.94237348, DT.97365240
Consensus CDS Project CCDS15736.1, CCDS38064.1
UniGene 882
DFCI TC1575079, TC1632112, TC1684436
NIA Mouse Gene Index U001468
Entrez Gene 16181
VEGA Gene Model OTTMUSG00000011966
International Mouse Knockout Project Status Il1rn
Protein
domains
InterPro ID Description
IPR000975 Interleukin-1
IPR003297 Interleukin-1 receptor antagonist IL1RA
IPR008996 Cytokine, IL-1-like
IPR020877 Interleukin-1 conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:14587 Eisenberg SP et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist." Nature 1990 Jan 25;343(6256):341-6
(Latest) J:154541 Lu P et al., "Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist." Invest Ophthalmol Vis Sci 2009 Oct;50(10):4761-8
All references(79)
Other
accession IDs 		MGD-MRK-11373, MGI:2443250
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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