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Ghr Gene Detail
 Symbol
Name
ID
Ghr
growth hormone receptor
MGI:95708

Nomenclature History
Synonyms GHBP, GHR/BP
Genetic Map
Chromosome 15
4.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 22)

Sequence Map
Chr15:3267760-3533492 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rabbit, European; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Ghr ± 2 cM)
Protein SuperFamily: growth hormone receptor
TreeFam: TF330851
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030599 VEGA Gene Model | MGI Sequence Detail 265733 C57BL/6J ± Kb
transcript NM_010284 RefSeq | MGI Sequence Detail 4178 C57BL/6
polypeptide P16882 UniProt | EBI | MGI Sequence Detail 650 Not Applicable
For the selected sequences
All sequences(64)
Alleles
and
phenotypes 		All alleles(9) : Targeted, knock-out(5) Targeted, other(4)
Homozygotes for targeted null mutations exhibit retarded postnatal growth, proportionate dwarfism, decreased plasma insulin-like growth factor I levels, small pituitaries, reduced fecundity in females, and extended life-span.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms RFLP(4) SNPs within 2kb(717 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process 2-oxoglutarate metabolic process, allantoin metabolic process...
Component extracellular region, extrinsic to membrane...
Function cytokine receptor activity, growth hormone receptor activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Assays (17)    Results (197)    Tissues (49)    Images (3)
Theiler Stages: 22,23,24,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RT-PCR 4   140
      Northern blot 8   28
      RNase protection 4   28
cDNA source data(133)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(151) Genomic(5) cDNA(135) Primer pair(3) Other(8) Antibodies(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000055737
DoTS DT.101161259, DT.101372114, DT.101372115, DT.102519877, DT.532344, DT.91382251, DT.94159849, DT.97391461
Consensus CDS Project CCDS27358.1, CCDS37024.1
UniGene 3986
DFCI TC1576161, TC1585601, TC1596129, TC1596906, TC1597006, TC1607843
NIA Mouse Gene Index U035969
Entrez Gene 14600
VEGA Gene Model OTTMUSG00000030599
International Mouse Knockout Project Status Ghr
Protein
domains
InterPro ID Description
IPR003528 Long hematopoietin receptor, single chain, conserved site
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR015152 Erythropoietin receptor, ligand binding
Graphical View of Protein Domain Structure
References
(Earliest) J:7060 Herington AC et al., "Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse." Endocrinology 1983 Jun;112(6):2032-8
(Latest) J:155335 Barclay JL et al., "In Vivo Targeting of the Growth Hormone Receptor (GHR) Box1 Sequence Demonstrates that the GHR Does Not Signal Exclusively through JAK2." Mol Endocrinol 2009 Nov 2;():
All references(130)
Other
accession IDs 		MGD-MRK-10070, MGI:2145937
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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