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Gfap Gene Detail
 Symbol
Name
ID
Gfap
glial fibrillary acidic protein
MGI:95697

Nomenclature History
STS D11Nds5,D11Nds7
Genetic Map
Chromosome 11
62.0 cM, cytoband D
Detailed Genetic Map ± 1 cM
 
Mapping data( 21)

Sequence Map
Chr11:102748650-102762226 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gfap ± 2 cM)
Protein SuperFamily: cytoskeletal keratin
TreeFam: TF330122
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003084 VEGA Gene Model | MGI Sequence Detail 13577 C57BL/6J ± Kb
transcript NM_010277 RefSeq | MGI Sequence Detail 2733 C57BL/6
polypeptide P03995 UniProt | EBI | MGI Sequence Detail 430 Not Applicable
For the selected sequences
All sequences(43)
Alleles
and
phenotypes 		All alleles(10) : Targeted, knock-out(3) Targeted, other(7)
Homozygotes for targeted null mutations show reduced astrocyte-associated intermediate filaments, enhanced long-term potentiation and impaired eye-blink conditioning. Aged mutants may show hydrocephaly, reduced myelination and impaired blood-brain barrier.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms All PCR and RFLP(19) : PCR(14) RFLP(5) SNPs within 2kb(127 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process intermediate filament-based process
Component cell part, cytoplasm...
Function protein binding, structural molecule activity...
External Resources: FuncBase
Expression Literature Summary: (325 records)
Data Summary: Assays (26)    Results (200)    Tissues (141)    Images (44)
Theiler Stages: 16,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RT-PCR 6   35
      RNA in situ 2   94
      Immunohistochemistry 13   45
      Nuclease S1 2   14
      Northern blot 2   11
cDNA source data(246)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(269) Genomic(6) cDNA(246) Primer pair(14) Other(3) Antibodies(10)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020932
DoTS DT.94156536, DT.94245606
Consensus CDS Project CCDS25507.1
UniGene 1239
DFCI TC1640428, TC1648992
NIA Mouse Gene Index U033490
Entrez Gene 14580
VEGA Gene Model OTTMUSG00000003084
International Mouse Knockout Project Status Gfap
Protein
domains
InterPro ID Description
IPR001664 Intermediate filament protein
IPR006821 Intermediate filament, DNA-binding region
IPR016044 Filament
IPR018039 Intermediate filament protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:7424 Lewis SA et al., "Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments." Proc Natl Acad Sci U S A 1984 May;81(9):2743-6
(Latest) J:155511 Fuchs P et al., "Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity." J Biol Chem 2009 Sep 25;284(39):26502-9
All references(410)
Other
accession IDs 		MGD-MRK-10055, MGI:2144272
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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