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Mecom Gene Detail
 Symbol
Name
ID
Mecom
MDS1 and EVI1 complex locus
MGI:95457


Nomenclature History
Synonyms D630039M04Rik, Evi-1, Evi1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1
Genetic Map
Chromosome 3
14.4 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 35)

Sequence Map
Chr3:30135491-30139439 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Mecom ± 2 cM)
Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
TreeFam: TF315309
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000051636 Ensembl Gene Model | MGI Sequence Detail 3949 C57BL/6J ± Kb
transcript AK033517 GenBank | EMBL | DDBJ | MGI Sequence Detail 3852 C57BL/6J
polypeptide P14404 UniProt | EBI | MGI Sequence Detail 1042 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes
All alleles(4) : Targeted, knock-out(2) Targeted, other(1) Chemically induced(1)
Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms RFLP(9) SNPs within 2kb(353 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis...
Component intracellular, nucleus...
Function DNA binding, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (6)    Results (137)    Tissues (131)    Images (25)
Theiler Stages: 17,21,22,23,25,28
  Assay Type Assays   Results
      RT-PCR 2   8
      RNA in situ 3   126
      Northern blot 1   3
cDNA source data(14)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(26) Genomic(6) cDNA(14) Primer pair(3) Other(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027684, ENSMUSG00000051636
DoTS DT.101369633, DT.87038324, DT.94213381, DT.94275571, DT.97357747
Consensus CDS Project CCDS17281.1
DFCI TC1584289, TC1587590, TC1590789, TC1651101, TC1680747
NIA Mouse Gene Index U023905
Entrez Gene 14013
International Mouse Knockout Project Status Mecom
Protein
domains
InterPro ID Description
IPR001214 SET domain
IPR007087 Zinc finger, C2H2-type
IPR013087 Zinc finger, C2H2-type/integrase, DNA-binding
IPR015880 Zinc finger, C2H2-like
Graphical View of Protein Domain Structure
References
(Earliest) J:6439 Chattopadhyay SK et al., "Structure of endogenous murine leukemia virus DNA in mouse genomes." Proc Natl Acad Sci U S A 1980 Oct;77(10):5774-8
(Latest) J:156032 Shimabe M et al., "Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells." Oncogene 2009 Dec 10;28(49):4364-74
All references(56)
Other
accession IDs
MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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