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Ebf1 Gene Detail
 Symbol
Name
ID
Ebf1
early B-cell factor 1
MGI:95275

Nomenclature History
Synonyms O/E-1, Olf-1, Olf1
Genetic Map
Chromosome 11
20.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr11:44430819-44821593 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ebf1 ± 2 cM)
Protein SuperFamily: transcription factor, collier type
TreeFam: TF313391
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005474 VEGA Gene Model | MGI Sequence Detail 390775 C57BL/6J ± Kb
transcript NM_007897 RefSeq | MGI Sequence Detail 2248 C57BL/6
polypeptide Q07802 UniProt | EBI | MGI Sequence Detail 591 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes 		All alleles(20) : Targeted, knock-out(1) Gene trapped(19)
Homozygotes for a targeted null mutation exhibit a reduced striatum due to excess apoptosis, altered facial branchiomotor neurone migration, and a block in B cell differentiation. Mutants are smaller than normal and many die prior to 4 weeks of age.
Polymorphisms RFLP(2) SNPs within 2kb(2051 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process multicellular organismal development, positive regulation of transcription...
Component nucleus
Function DNA binding, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (63 records)
Data Summary: Assays (23)    Results (281)    Tissues (180)    Images (90)
Theiler Stages: 2,3,4,5,17,18,19,20,21,22,23,26,28
  Assay Type Assays   Results
      RT-PCR 4   21
      RNA in situ 16   237
      Immunohistochemistry 3   23
cDNA source data(20)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(38) Genomic(3) cDNA(23) Primer pair(6) Other(6) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000057098, ENSMUSG00000078561
DoTS DT.101708900, DT.525987, DT.91445319
Consensus CDS Project CCDS24566.1
DFCI TC1576969, TC1583937, TC1607236, TC1620167
NIA Mouse Gene Index U012493, U181605
Entrez Gene 13591
VEGA Gene Model OTTMUSG00000005474
International Mouse Knockout Project Status Ebf1
Protein
domains
InterPro ID Description
IPR001092 Helix-loop-helix DNA-binding domain
IPR002909 Cell surface receptor IPT/TIG
IPR003523 Transcription factor COE
IPR014756 Immunoglobulin E-set
IPR018350 Transcription factor COE, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:4971 Hagman J et al., "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression." Genes Dev 1993 May;7(5):760-73
(Latest) J:153550 Yu W et al., "Patterning of ventral telencephalon requires positive function of Gli transcription factors." Dev Biol 2009 Oct 1;334(1):264-75
All references(90)
Other
accession IDs 		MGD-MRK-9290, MGI:2144593
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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