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Cybb Gene Detail
 Symbol
Name
ID
Cybb
cytochrome b-245, beta polypeptide
MGI:88574


Nomenclature History
Synonyms Cgd, gp91phox, gp91phox, Nox2
Genetic Map
Chromosome X
Syntenic
 
Mapping data( 22)
Sequence Map
ChrX:9012378-9046450 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF105354
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016894 VEGA Gene Model | MGI Sequence Detail 34073 C57BL/6J ± Kb
transcript NM_007807 RefSeq | MGI Sequence Detail 4752 C57BL/6
polypeptide Q61093 UniProt | EBI | MGI Sequence Detail 570 Not Applicable
For the selected sequences
All sequences(43)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(3) SNPs within 2kb(186 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process electron transport chain, hydrogen peroxide biosynthetic process...
Component cytoplasm, integral to membrane...
Function electron carrier activity, FAD binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (4)    Results (99)    Tissues (50)    Images (2)
Theiler Stages: 23,26,28
  Assay Type Assays   Results
      RT-PCR 3   93
      Northern blot 1   6
cDNA source data(20)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(23) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000015340
DoTS DT.101165428, DT.534026
Consensus CDS Project CCDS30010.1
DFCI TC1574823, TC1599555, TC1746473
Entrez Gene 13058
VEGA Gene Model OTTMUSG00000016894
International Mouse Knockout Project Status Cybb
Protein
domains
InterPro ID Description
IPR000778 Cytochrome b245, heavy chain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase-like transmembrane component, N-terminal
IPR017927 Ferredoxin reductase-type FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel
Graphical View of Protein Domain Structure
References
(Earliest) J:9438 Ryder-Cook AS et al., "Localization of the mdx mutation within the mouse dystrophin gene." EMBO J 1988 Oct;7(10):3017-21
(Latest) J:156427 Bae YS et al., "Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2." Circ Res 2009 Jan 30;104(2):210-8, 21p following 218
All references(209)
Other
accession IDs
MGD-MRK-1965, MGD-MRK-2263, MGI:2148082

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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