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Cr2 Gene Detail
 Symbol
Name
ID
Cr2
complement receptor 2
MGI:88489


Nomenclature History
Synonyms C3DR, CD21, CD35, Cr-1, Cr-2, Cr1
Genetic Map
Chromosome 1
106.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr1:196963005-197002909 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cr2 ± 2 cM)
TreeFam: TF316872
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12902 NCBI Gene Model | MGI Sequence Detail 39905 C57BL/6J ± Kb
transcript NM_007758 RefSeq | MGI Sequence Detail 6207 C57BL/6
polypeptide P19070 UniProt | EBI | MGI Sequence Detail 1025 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(4) Targeted, other(1)
Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(153 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process B cell activation, complement activation, classical pathway...
Component external side of plasma membrane, integral to membrane...
Function complement receptor activity, protein binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (42)    Tissues (31)
Theiler Stages: 16,18,20,21,23,25,28
  Assay Type Assays   Results
      RT-PCR 1   42
cDNA source data(35)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(51) Genomic(12) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000026616
DoTS DT.91336425, DT.91336426, DT.94230296
Consensus CDS Project CCDS15642.1
UniGene 235387
DFCI TC1586370, TC1597325, TC1599433, TC1601030
NIA Mouse Gene Index U022233
Entrez Gene 12902
International Mouse Knockout Project Status Cr2
Protein
domains
InterPro ID Description
IPR000436 Sushi/SCR/CCP
IPR016060 Complement control module
Graphical View of Protein Domain Structure
References
(Earliest) J:7312 Bubbers JE, "Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression." J Natl Cancer Inst 1984 Feb;72(2):441-6
(Latest) J:155241 Roundy KM et al., "Deletion of putative intronic control sequences does not alter cell or stage specific expression of Cr2." Mol Immunol 2009 Dec;47(2-3):517-25
All references(110)
Other
accession IDs
MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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