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Cdc25c Gene Detail
 Symbol
Name
ID
Cdc25c
cell division cycle 25 homolog C (S. pombe)
MGI:88350


Nomenclature History
Synonyms Cdc25
Genetic Map
Chromosome 18
15.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr18:34892651-34911181 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cdc25c ± 2 cM)
Protein SuperFamily: protein-tyrosine-phosphatase Cdc25C
TreeFam: TF101056
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000044201 Ensembl Gene Model | MGI Sequence Detail 18531 C57BL/6J ± Kb
transcript NM_009860 RefSeq | MGI Sequence Detail 1941 C57BL/6
polypeptide P48967 UniProt | EBI | MGI Sequence Detail 447 Not Applicable
For the selected sequences
All sequences(25)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(1) Gene trapped(7)
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.
Polymorphisms RFLP(1) SNPs within 2kb(144 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell division...
Component cytoplasm, intracellular...
Function hydrolase activity, phosphoprotein phosphatase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
cDNA source data(40)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(2)
Other database
links
EC 3.1.3.48
Ensembl Gene Model ENSMUSG00000044201
DoTS DT.525527, DT.55114045, DT.99850667
Consensus CDS Project CCDS37759.1
UniGene 286602
DFCI TC1579191, TC1596235, TC1672590
NIA Mouse Gene Index U038313
Entrez Gene 12532
International Mouse Knockout Project Status Cdc25c
Protein
domains
InterPro ID Description
IPR000751 M-phase inducer phosphatase
IPR001763 Rhodanese-like
Graphical View of Protein Domain Structure
References
(Earliest) J:1241 Sartor H et al., "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively." Genomics 1992 Jul;13(3):911-2
(Latest) J:145768 Lee G et al., "Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion." Proc Natl Acad Sci U S A 2009 Mar 9;():
All references(17)
Other
accession IDs
MGD-MRK-1876, MGD-MRK-1877

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory