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Cd48 Gene Detail
 Symbol
Name
ID
Cd48
CD48 antigen
MGI:88339

Nomenclature History
Synonyms Bcm-1, BCM1, BLAST-1, Sgp-60
Genetic Map
Chromosome 1
93.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 20)

Sequence Map
Chr1:173612140-173635389 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd48 ± 2 cM)
Protein SuperFamily: B-cell surface glycoprotein blast-1
TreeFam: TF334964
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016904 VEGA Gene Model | MGI Sequence Detail 23250 C57BL/6J ± Kb
transcript NM_007649 RefSeq | MGI Sequence Detail 1142 C57BL/6
polypeptide P18181 UniProt | EBI | MGI Sequence Detail 240 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygous mutation of this gene results in a slight increase in CD4+CD8- thymocytes and impaired T cell proliferation in response to mitogens, anti-CD3 antibodies, and alloantigens.
Polymorphisms RFLP(2) SNPs within 2kb(126 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process response to protein stimulus, signal transduction...
Component anchored to membrane, external side of plasma membrane...
Function eukaryotic cell surface binding, protein binding...
External Resources: FuncBase
Expression cDNA source data(48)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(67) Genomic(17) cDNA(48) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000015355
DoTS DT.491780, DT.94181119
Consensus CDS Project CCDS15501.1
UniGene 1738
PDB 2PTT, 2PTV
DFCI TC1577876, TC1594850
NIA Mouse Gene Index U001094
Entrez Gene 12506
VEGA Gene Model OTTMUSG00000016904
International Mouse Knockout Project Status Cd48
Protein
domains
InterPro ID Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR013106 Immunoglobulin V-set
IPR013151 Immunoglobulin
IPR013783 Immunoglobulin-like fold
IPR015631 Signalling lymphocyte activation molecule
Graphical View of Protein Domain Structure
References
(Earliest) J:10552 Wong YW et al., "Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3." J Exp Med 1990 Jun 1;171(6):2115-30
(Latest) J:145577 Levi BP et al., "Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems." Blood 2009 Feb 19;113(8):1670-80
All references(30)
Other
accession IDs 		MGD-MRK-1529, MGD-MRK-1865, MGI:2138248, MGI:2138623
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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