Symbol
Name
ID
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Synonyms
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Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(90)
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Alleles
and
phenotypes
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All alleles(14) :
Targeted, knock-out(5)
Targeted, other(9)
| Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (4)
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Polymorphisms
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All PCR and RFLP(13) :
PCR(1)
RFLP(12)
SNPs within 2kb(1328 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (23 records)
Data Summary:
Assays (4)
Results (83)
Tissues (82)
Images (4)
Theiler Stages: 11,13,15,17,20,22,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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16 |
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RNA in situ |
3 |
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67 |
cDNA source data(23)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(37)
Genomic(4)
cDNA(30)
Primer pair(2)
Other(1)
Microarray probesets(3)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000022892 |
| DoTS |
DT.101190035, DT.101226146, DT.101287752, DT.102548873, DT.103577624, DT.110737942, DT.91330139, DT.94144862, DT.94144936, DT.94312819, DT.94344131, DT.97368194, DT.97390493, DT.97390518, DT.97390521, DT.99867790 |
| Consensus CDS Project |
CCDS28285.1 |
| PDB |
2ROZ, 2YSZ, 2YT0, 2YT1 |
| DFCI |
TC1573751, TC1598258, TC1601541, TC1603938 |
| NIA Mouse Gene Index |
U037237, U188913, U376466 |
| Entrez Gene |
11820 |
| International Mouse Knockout Project Status |
App |
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Protein
domains
|
| InterPro ID |
Description |
| IPR002223 |
Proteinase inhibitor I2, Kunitz metazoa |
| IPR008154 |
Amyloidogenic glycoprotein, extracellular |
| IPR008155 |
Amyloidogenic glycoprotein |
| IPR011178 |
Amyloidogenic glycoprotein, copper-binding |
| IPR013803 |
Amyloidogenic glycoprotein, amyloid-beta peptide |
| IPR015849 |
Amyloidogenic glycoprotein, heparin-binding |
| IPR019543 |
Beta-amyloid precursor protein C-terminal |
| IPR019744 |
Amyloidogenic glycoprotein, extracellular domain conserved site |
| IPR019745 |
Amyloidogenic glycoprotein, intracellular domain, conserved site |
| IPR020901 |
Proteinase inhibitor I2, Kunitz, conserved site |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:31044
McAdam KP et al.,
"Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis."
Int J Lepr Other Mycobact Dis 1977 Apr-Jun;45(2):150-7
(Latest)
J:155652
Xu F et al.,
"AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis."
J Neurosci 2009 Apr 29;29(17):5666-70
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All references(289)
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Other
accession IDs
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MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007
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Analysis Tools
MGI BioMart
