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Ank1 Gene Detail
 Symbol
Name
ID
Ank1
ankyrin 1, erythroid
MGI:88024


Nomenclature History
Synonyms Ank-1
Genetic Map
Chromosome 8
9.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr8:24085294-24260969 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ank1 ± 2 cM)
Protein SuperFamily: ankyrin
TreeFam: TF351263
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026381 VEGA Gene Model | MGI Sequence Detail 175676 C57BL/6J ± Kb
transcript NM_001110783 RefSeq | MGI Sequence Detail 8218 C57BL/6
polypeptide Q02357 UniProt | EBI | MGI Sequence Detail 1862 Not Applicable
For the selected sequences
All sequences(46)
Alleles
and
phenotypes
All alleles(4) : Targeted, other(2) Spontaneous(1) Chemically induced(1)
Homozygous mutant animals are anemic, infertile, and have reduced body size. Mutant animals also exhibit jaundice, bone marrow hyperplasia, splenomegaly, hepatomegaly, enlarged lymph nodes, increased white blood cell count, and cardiac hypertrophy.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(3) SNPs within 2kb(321 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process erythrocyte development, monovalent inorganic cation transport...
Component cortical cytoskeleton, cytoplasm...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (2)    Results (4)    Tissues (1)
Theiler Stages: 21
  Assay Type Assays   Results
      RT-PCR 1   2
      RNase protection 1   2
cDNA source data(17)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031543
DoTS DT.101161410, DT.110867054, DT.110867066, DT.110867074, DT.527812, DT.87038850, DT.87051370, DT.91337468, DT.94188023, DT.94188026
Consensus CDS Project CCDS22187.1
DFCI TC1576228, TC1582131, TC1588437, TC1622029, TC1670415
NIA Mouse Gene Index U009178
Entrez Gene 11733
VEGA Gene Model OTTMUSG00000026381
International Mouse Knockout Project Status Ank1
Protein
domains
InterPro ID Description
IPR000488 Death
IPR000906 ZU5
IPR002110 Ankyrin repeat
IPR011029 DEATH-like
IPR020683 Ankyrin repeat-containing domain
Graphical View of Protein Domain Structure
References
(Earliest) J:5247 Landaw SA, "Kinetic aspects of endogenous carbon monoxide production in experimental animals." Ann N Y Acad Sci 1970 Oct 5;174(1):32-48
(Latest) J:148127 Rank G et al., "Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant." Blood 2009 Apr 2;113(14):3352-62
All references(41)
Other
accession IDs
MGD-MRK-12782, MGD-MRK-1324, MGD-MRK-1327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory