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Add2 Gene Detail
 Symbol
Name
ID
Add2
adducin 2 (beta)
MGI:87919


Nomenclature History
Synonyms 2900072M03Rik
Genetic Map
Chromosome 6
35.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr6:86028078-86069549 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Add2 ± 2 cM)
TreeFam: TF313003
Sequences
Representative Sequences Length Strain/Species Flank
genomic 11519 NCBI Gene Model | MGI Sequence Detail 41472 C57BL/6J ± Kb
transcript NM_013458 RefSeq | MGI Sequence Detail 3119 C57BL/6
polypeptide Q9QYB8 UniProt | EBI | MGI Sequence Detail 725 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Gene trapped(1)
Mice homozygous for targeted mutations that inactivate the gene display mild anemia with compensated hemolysis, marked alteration in osmotic fragility, predominant presence of elliptocytes in the blood and increased blood pressure.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)  
Polymorphisms RFLP(2) SNPs within 2kb(197 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process hemopoiesis
Component cytoplasm, cytoskeleton...
Function actin binding, calmodulin binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (3)    Tissues (3)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   3
cDNA source data(76)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030000
DoTS DT.101364124, DT.101715945, DT.40139230, DT.528092, DT.94172124
Consensus CDS Project CCDS20308.1
UniGene 104155
DFCI TC1577110, TC1584489, TC1642182, TC1654427
NIA Mouse Gene Index U007110
Entrez Gene 11519
International Mouse Knockout Project Status Add2
Protein
domains
InterPro ID Description
IPR001303 Class II aldolase/adducin, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:33510 Pinto-Correia C et al., "Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes." Dev Biol 1991 Aug;146(2):301-11
(Latest) J:149737 Sansom SN et al., "The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis." PLoS Genet 2009 Jun;5(6):e1000511
All references(24)
Other
accession IDs
MGD-MRK-1109, MGI:1920220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory