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Acta2 Gene Detail
 Symbol
Name
ID
Acta2
actin, alpha 2, smooth muscle, aorta
MGI:87909


Nomenclature History
Synonyms 0610041G09Rik, a-SMA, Actvs, SMalphaA
Genetic Map
Chromosome 19
cytoband C3
 
Mapping data( 2)
Sequence Map
Chr19:34316014-34329810 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic    (Mammalian Orthology)
Protein SuperFamily: Actin
TreeFam: TF300361
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000035783 Ensembl Gene Model | MGI Sequence Detail 13797 C57BL/6J ± Kb
transcript NM_007392 RefSeq | MGI Sequence Detail 1780 C57BL/6
polypeptide P62737 UniProt | EBI | MGI Sequence Detail 377 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Gene trapped(2)
Polymorphisms SNPs within 2kb(166 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process regulation of blood pressure, vascular smooth muscle contraction...
Component actin cytoskeleton, cytoplasm...
Function ATP binding, nucleotide binding...
External Resources: FuncBase
Expression Literature Summary: (406 records)
Data Summary: Assays (29)    Results (161)    Tissues (70)    Images (86)
Theiler Stages: 14,15,16,17,18,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 1   6
      RT-PCR 2   23
      RNA in situ 3   9
      Immunohistochemistry 23   123
cDNA source data(372)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(382) Genomic(7) cDNA(372) Primer pair(2) Other(1) Antibodies(4)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000035783
DoTS DT.87075094, DT.97375089, DT.99868907
Consensus CDS Project CCDS29757.1
UniGene 213025
DFCI TC1573391, TC1612174
NIA Mouse Gene Index U038980
Entrez Gene 11475
International Mouse Knockout Project Status Acta2
Protein
domains
InterPro ID Description
IPR004000 Actin/actin-like
IPR004001 Actin, conserved site
IPR020902 Actin/actin-like conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:9473 Min BH et al., "Nucleotide sequence of a mouse vascular smooth muscle alpha-actin cDNA." Nucleic Acids Res 1988 Nov 11;16(21):10374
(Latest) J:155633 Pavone LM et al., "Serotonin transporter gene deficiency is associated with sudden death of newborn mice through activation of TGF-beta1 signalling." J Mol Cell Cardiol 2009 Nov;47(5):691-7
All references(430)
Other
accession IDs
MGD-MRK-1095, MGI:1915627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory