About   Help   FAQ
Ace Gene Detail
 Symbol
Name
ID
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
MGI:87874


Nomenclature History
STS D11Mit13
Synonyms CD143
Genetic Map
Chromosome 11
65.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr11:105829259-105851278 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ace ± 2 cM)
TreeFam: TF312861
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003113 VEGA Gene Model | MGI Sequence Detail 22020 C57BL/6J ± Kb
transcript NM_207624 RefSeq | MGI Sequence Detail 4885 C57BL/6
polypeptide P09470 UniProt | EBI | MGI Sequence Detail 1312 Not Applicable
For the selected sequences
All sequences(39)
Alleles
and
phenotypes
All alleles(11) : Targeted, knock-out(6) Targeted, other(5)
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
Polymorphisms SNPs within 2kb(94 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process hormone catabolic process, proteolysis...
Component extracellular region, integral to membrane...
Function carboxypeptidase activity, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (2)    Results (47)    Tissues (46)    Images (2)
Theiler Stages: 22,23,28
  Assay Type Assays   Results
      RT-PCR 1   46
      RNA in situ 1   1
cDNA source data(125)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(135) Genomic(8) cDNA(126) Primer pair(1)
Microarray probesets(3)
Other database
links
EC 3.4.15.1
Ensembl Gene Model ENSMUSG00000020681
DoTS DT.40186624, DT.97340483, DT.97393465, DT.97393466
Consensus CDS Project CCDS25543.1, CCDS25544.1
UniGene 754
DFCI TC1578619, TC1597179
NIA Mouse Gene Index U013459
Entrez Gene 11421
VEGA Gene Model OTTMUSG00000003113
International Mouse Knockout Project Status Ace
Protein
domains
InterPro ID Description
IPR001548 Peptidase M2, peptidyl-dipeptidase A
Graphical View of Protein Domain Structure
References
(Earliest) J:21460 Bernstein KE et al., "The isolation of angiotensin-converting enzyme cDNA." J Biol Chem 1988 Aug 15;263(23):11021-4
(Latest) J:153990 Machura K et al., "Developmental renin expression in mice with a defective renin-angiotensin system." Am J Physiol Renal Physiol 2009 Nov;297(5):F1371-80
All references(74)
Other
accession IDs
MGD-MRK-1032, MGI:2144508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory