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Klre1 Gene Detail
 Symbol
Name
ID
Klre1
killer cell lectin-like receptor family E member 1
MGI:2662547

Nomenclature History
Synonyms Klre-1, NKG2I
Genetic Map
Chromosome 6
Syntenic
 
Mapping data( 1)
Sequence Map
Chr6:129527911-129535842 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
rat    (Mammalian Orthology)
Protein SuperFamily: natural killer cell receptor CD94/NKG2
TreeFam: TF336674
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000050241 Ensembl Gene Model | MGI Sequence Detail 7932 C57BL/6J ± Kb
transcript NM_153590 RefSeq | MGI Sequence Detail 927 C57BL/6
polypeptide NP_705818 RefSeq | MGI Sequence Detail 226 C57BL/6
For the selected sequences
All sequences(19)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous null mice are viable and fertile and display impaired natural killer cell mediated allogeneic cytotoxicity.
Polymorphisms SNPs within 2kb(70 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process natural killer cell activation, positive regulation of interferon-gamma production...
Component external side of plasma membrane, integral to plasma membrane...
Function protein dimerization activity, receptor activity...
External Resources: FuncBase
Expression cDNA source data(3)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(4) cDNA(3) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000050241
DoTS DT.91380324, DT.94192712
Consensus CDS Project CCDS20589.1
UniGene 30968
DFCI TC1589786, TC1612575
Entrez Gene 243655
International Mouse Knockout Project Status Klre1
Protein
domains
InterPro ID Description
IPR001304 C-type lectin
IPR016186 C-type lectin-like
IPR016187 C-type lectin fold
References
(Earliest) J:83529 Wilhelm BT et al., "Identification of a new murine lectin-like gene in close proximity to CD94." Immunogenetics 2003 Apr;55(1):53-6
(Latest) J:138955 Saether PC et al., "KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity." J Immunol 2008 Sep 1;181(5):3177-82
All references(7)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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