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Cadps2 Gene Detail
 Symbol
Name
ID
Cadps2
Ca2+-dependent activator protein for secretion 2
MGI:2443963

Nomenclature History
Synonyms A230044C21Rik, Cadps2, Caps2, cpd2
Genetic Map
Chromosome 6
Syntenic
 
Mapping data( 2)
Sequence Map
Chr6:23212773-23789420 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: calcium-dependent actin-binding protein
TreeFam: TF312963
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022856 VEGA Gene Model | MGI Sequence Detail 576648 C57BL/6J ± Kb
transcript NM_153163 RefSeq | MGI Sequence Detail 4783 C57BL/6
polypeptide Q8BYR5 UniProt | EBI | MGI Sequence Detail 1297 Not Applicable
For the selected sequences
All sequences(58)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(2) Gene trapped(4)
Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(2481 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process exocytosis, positive regulation of exocytosis...
Component cell junction, cytoplasmic membrane-bounded vesicle...
Function calcium ion binding, lipid binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (5)    Results (14)    Tissues (4)
Theiler Stages: 26,28
  Assay Type Assays   Results
      Western blot 3   10
      RNA in situ 1   2
      Immunohistochemistry 1   2
cDNA source data(12)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(12) cDNA(12) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000017978
DoTS DT.101124362, DT.101366715, DT.87047862, DT.91283315, DT.91421993, DT.91588032, DT.94267473, DT.99550327
Consensus CDS Project CCDS39439.1
DFCI TC1582295, TC1593298, TC1595787, TC1596158, TC1612785, TC1619883, TC1625115
NIA Mouse Gene Index U006593, U027080
Entrez Gene 320405
VEGA Gene Model OTTMUSG00000022856
International Mouse Knockout Project Status Cadps2
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR001849 Pleckstrin homology
IPR010439 Protein of unknown function DUF1041
IPR011993 Pleckstrin homology-type
IPR014770 Munc13 homology 1
Graphical View of Protein Domain Structure
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" Nature 2002;420():563-573
(Latest) J:149599 Eran A et al., "Comment on 'Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients'." J Clin Invest 2009 Apr;119(4):679-80; author reply 680-1
All references(16)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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