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Lyve1 Gene Detail
 Symbol
Name
ID
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
MGI:2136348


Nomenclature History
Synonyms 1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
Genetic Map
Chromosome 7
cytoband F2
 
Mapping data( 2)
Sequence Map
Chr7:117994121-118006467 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF334173
Sequences
Representative Sequences Length Strain/Species Flank
genomic 114332 NCBI Gene Model | MGI Sequence Detail 12347 C57BL/6J ± Kb
transcript NM_053247 RefSeq | MGI Sequence Detail 2607 C57BL/6
polypeptide Q8BHC0 UniProt | EBI | MGI Sequence Detail 318 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
Polymorphisms SNPs within 2kb(54 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell adhesion, glycosaminoglycan catabolic process...
Component integral to membrane, membrane...
Function binding, hyaluronic acid binding...
External Resources: FuncBase
Expression Literature Summary: (45 records)
Data Summary: Assays (3)    Results (36)    Tissues (16)    Images (19)
Theiler Stages: 15,17,18,20,21,22,25
  Assay Type Assays   Results
      Immunohistochemistry 3   36
cDNA source data(39)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(39) cDNA(39) Antibodies(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030787
DoTS DT.532198
Consensus CDS Project CCDS21748.1
UniGene 396078
DFCI TC1579373
NIA Mouse Gene Index U029123
Entrez Gene 114332
International Mouse Knockout Project Status Lyve1
Protein
domains
InterPro ID Description
IPR000538 Link
IPR016186 C-type lectin-like
IPR016187 C-type lectin fold
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:152968 Bazigou E et al., "Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis." Dev Cell 2009 Aug;17(2):175-86
All references(57)
Other
accession IDs
MGI:1914711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory