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Tnfrsf25 Gene Detail
 Symbol
Name
ID
Tnfrsf25
tumor necrosis factor receptor superfamily, member 25
MGI:1934667

Nomenclature History
Synonyms APO-3, DDR3, DR3, LARD, Tnfrsf12, TR3, TRAMP, Wsl, WSL-1, WSL-LR
Genetic Map
Chromosome 4
cytoband E1
 
Mapping data( 1)
Sequence Map
Chr4:151490043-151494228 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF333916
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000010224 VEGA Gene Model | MGI Sequence Detail 4186 C57BL/6J ± Kb
transcript NM_033042 RefSeq | MGI Sequence Detail 1619 FVB/N
polypeptide NP_149031 RefSeq | MGI Sequence Detail 387 FVB/N
For the selected sequences
All sequences(16)
Alleles
and
phenotypes 		All alleles(2) : Targeted, other(1) Gene trapped(1)
Homozygous mutant mice show no developmental defects or impairments of early thymocyte development. Negative selection and anti-CD3-induced apoptosis, however, are significantly impaired.
Polymorphisms SNPs within 2kb(25 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component plasma membrane
Function receptor activity
External Resources: FuncBase
Expression cDNA source data(5)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(7) Genomic(2) cDNA(5)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024793
DoTS DT.101313743, DT.87048340, DT.94176068
Consensus CDS Project CCDS38983.1
UniGene 101198
DFCI TC1588829
NIA Mouse Gene Index U005163
Entrez Gene 85030
VEGA Gene Model OTTMUSG00000010224
International Mouse Knockout Project Status Tnfrsf25
Protein
domains
InterPro ID Description
IPR000488 Death
IPR001368 TNFR/CD27/30/40/95 cysteine-rich region
IPR011029 DEATH-like
References
(Earliest) J:68679 Wang EC et al., "Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene." Immunogenetics 2001 Feb;53(1):59-63
(Latest) J:143474 Bull MJ et al., "The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis." J Exp Med 2008 Oct 27;205(11):2457-64
All references(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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