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Bcl11b Gene Detail
 Symbol
Name
ID
Bcl11b
B-cell leukemia/lymphoma 11B
MGI:1929913


Nomenclature History
Synonyms 9130430L19Rik, B630002E05Rik, COUP-TF interacting protein 2, CTIP2, Rit1
Genetic Map
Chromosome 12
52.0 cM, cytoband F1
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr12:109148613-109241812 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Bcl11b ± 2 cM)
TreeFam: TF318131
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000019485 VEGA Gene Model | MGI Sequence Detail 93200 C57BL/6J ± Kb
transcript NM_001079883 RefSeq | MGI Sequence Detail 7923 C57BL/6
polypeptide Q99PV8 UniProt | EBI | MGI Sequence Detail 884 Not Applicable
For the selected sequences
All sequences(37)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(1)
Animals homozygous for a mutation of this gene are born with open eyes, exhibit abnormalities of the thymus, and die within 1 day after birth.
Polymorphisms SNPs within 2kb(417 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process alpha-beta T cell differentiation, axonogenesis...
Component intracellular, nucleus...
Function metal ion binding, nucleic acid binding...
External Resources: FuncBase
Expression Literature Summary: (29 records)
Data Summary: Assays (4)    Results (45)    Tissues (44)    Images (5)
Theiler Stages: 17,18,19,20,21,28
  Assay Type Assays   Results
      RT-PCR 1   11
      RNA in situ 2   33
      Northern blot 1   1
cDNA source data(60)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000048251
DoTS DT.101329370, DT.101721120, DT.486535, DT.528032
Consensus CDS Project CCDS36552.1, CCDS36553.1
UniGene 392694
DFCI TC1583807, TC1595108, TC1598959, TC1615876, TC1625299
NIA Mouse Gene Index U034331
Entrez Gene 58208
VEGA Gene Model OTTMUSG00000019485
International Mouse Knockout Project Status Bcl11b
Protein
domains
InterPro ID Description
IPR007087 Zinc finger, C2H2-type
IPR013087 Zinc finger, C2H2-type/integrase, DNA-binding
IPR015880 Zinc finger, C2H2-like
Graphical View of Protein Domain Structure
References
(Earliest) J:61589 Avram D et al., "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors." J Biol Chem 2000 Apr 7;275(14):10315-22
(Latest) J:154611 Chou SJ et al., "Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex." Nat Neurosci 2009 Nov;12(11):1381-9
All references(42)
Other
accession IDs
MGI:1924922, MGI:1925932, MGI:2144864

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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