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Syne1 Gene Detail
 Symbol
Name
ID
Syne1
synaptic nuclear envelope 1
MGI:1927152

Nomenclature History
Synonyms 8B, A330049M09Rik, C130039F11Rik, CPG2, enaptin165, MGC:62825, Myne1, nesprin-1, SYNE-1, SYNE-1B
Genetic Map
Chromosome 10
cytoband A1
 
Mapping data( 3)
Sequence Map
Chr10:4795849-5326338 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF329280
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000019769 Ensembl Gene Model | MGI Sequence Detail 530490 C57BL/6J ± Kb
transcript NM_001079686 RefSeq | MGI Sequence Detail 10876 C57BL/6
polypeptide NP_001073154 RefSeq | MGI Sequence Detail 3010 C57BL/6
For the selected sequences
All sequences(58)
Alleles
and
phenotypes 		All alleles(7) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(2)
Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness.
Polymorphisms SNPs within 2kb(3308 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process establishment of nucleus localization
Component nuclear envelope, sarcomere...
Function actin binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (94)    Tissues (94)    Images (14)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   94
cDNA source data(48)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(49) cDNA(48) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019769
DoTS DT.101709129, DT.110605094, DT.40134247, DT.489673, DT.60108565, DT.91303942, DT.91335834, DT.91432549, DT.91563511, DT.97386325
Consensus CDS Project CCDS23676.1, CCDS35831.1
UniGene 331626
NIA Mouse Gene Index U031496, U323448
Entrez Gene 64009
International Mouse Knockout Project Status Syne1
Protein
domains
InterPro ID Description
IPR001589 Actinin-type, actin-binding, conserved site
IPR001715 Calponin-like actin-binding
IPR002017 Spectrin repeat
IPR012315 Klarsicht/ANC-1/syne-1 homology
IPR016146 Calponin-homology
IPR018159 Spectrin/alpha-actinin
References
(Earliest) J:65130 Apel ED et al., "Syne-1, A dystrophin- and klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction" J Biol Chem 2000 Oct 13;275(41):31986-95
(Latest) J:155342 Zhang J et al., "Nesprin 1 is critical for nuclear positioning and anchorage." Hum Mol Genet 2010 Jan 15;19(2):329-41
All references(16)
Other
accession IDs 		MGI:2441878, MGI:2443486, MGI:3034487
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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