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Ttc7 Gene Detail
 Symbol
Name
ID
Ttc7
tetratricopeptide repeat domain 7
MGI:1920999

Nomenclature History
Synonyms 1110035E02Rik, 1700007L07Rik, fsn, hea
Genetic Map
Chromosome 17
55.7 cM, cytoband E4
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr17:87682226-87781109 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ttc7 ± 2 cM)
TreeFam: TF313783
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000028525 VEGA Gene Model | MGI Sequence Detail 98884 C57BL/6J ± Kb
transcript NM_028639 RefSeq | MGI Sequence Detail 4605 C57BL/6
polypeptide Q8BGB2 UniProt | EBI | MGI Sequence Detail 858 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes 		All alleles(5) : Targeted, other(2) Spontaneous(3)
Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas.
Polymorphisms SNPs within 2kb(352 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cellular iron ion homeostasis, hemopoiesis...
Function binding
External Resources: FuncBase
Expression cDNA source data(71)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(72) cDNA(72)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000036918
DoTS DT.40174797, DT.87072388, DT.91421482, DT.97337987
Consensus CDS Project CCDS29016.1
UniGene 77396
DFCI TC1578451, TC1624268, TC1658761, TC1702346
NIA Mouse Gene Index U018321
Entrez Gene 225049
VEGA Gene Model OTTMUSG00000028525
International Mouse Knockout Project Status Ttc7
Protein
domains
InterPro ID Description
IPR001440 Tetratricopeptide TPR-1
IPR011990 Tetratricopeptide-like helical
IPR013026 Tetratricopeptide repeat-containing
IPR019734 Tetratricopeptide repeat
Graphical View of Protein Domain Structure
References
(Earliest) J:7515 Shimizu K et al., "Hereditary erythroblastic anaemia in the laboratory mouse." Lab Anim 1983 Jul;17(3):198-202
(Latest) J:147542 Takabayashi S et al., "The novel tetratricopeptide repeat domain 7 mutation, Ttc7fsn-Jic, with deletion of the TPR-2B repeat causes severe flaky skin phenotype." Exp Biol Med (Maywood) 2007 May;232(5):695-9
All references(32)
Other
accession IDs 		MGD-MRK-10690, MGD-MRK-9877, MGI:1922718, MGI:95584, MGI:96068
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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