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F12 Gene Detail
 Symbol
Name
ID
F12
coagulation factor XII (Hageman factor)
MGI:1891012

Nomenclature History
Synonyms FXII
Genetic Map
Chromosome 13
cytoband B2
 
Mapping data( 1)
Sequence Map
Chr13:55519349-55528148 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: coagulation factor XII/hepatocyte growth factor activator
TreeFam: TF329901
Sequences
Representative Sequences Length Strain/Species Flank
genomic 58992 NCBI Gene Model | MGI Sequence Detail 8800 C57BL/6J ± Kb
transcript NM_021489 RefSeq | MGI Sequence Detail 1961 C57BL/6
polypeptide NP_067464 RefSeq | MGI Sequence Detail 597 C57BL/6
For the selected sequences
All sequences(18)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process blood coagulation, regulation of blood coagulation...
Component extracellular space
Function hydrolase activity, peptidase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (16)    Tissues (13)
Theiler Stages: 11,13,15,17,19,20,21,22,23,28
  Assay Type Assays   Results
      RT-PCR 3   16
cDNA source data(50)
External Resources: GEO  ArrayExpress 
Molecular
reagents 		All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021492
DoTS DT.532017, DT.94192644
Consensus CDS Project CCDS36675.1
UniGene 42224
DFCI TC1582096
NIA Mouse Gene Index U034815
Entrez Gene 58992
International Mouse Knockout Project Status F12
Protein
domains
InterPro ID Description
IPR000001 Kringle
IPR000083 Fibronectin, type I
IPR000562 Type II fibronectin, collagen-binding
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1/S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR006209 EGF
IPR006210 EGF-like
IPR009003 Serine/cysteine peptidase, trypsin-like
IPR013032 EGF-like region, conserved site
IPR013806 Kringle-like fold
IPR014394 Coagulation factor XII/hepatocyte growth factor activator
IPR018056 Kringle, conserved site
IPR018059 Kringle, subgroup
IPR018114 Peptidase S1/S6, chymotrypsin/Hap, active site
References
(Earliest) J:74089 Ong K et al., "Early embryonic expression of murine coagulation system components." Thromb Haemost 2000 Dec;84(6):1023-30
(Latest) J:123758 Kleinschnitz C et al., "Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis." J Exp Med 2006 Mar 20;203(3):513-8
All references(7)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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