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Mapk13 Gene Detail
 Symbol
Name
ID
Mapk13
mitogen-activated protein kinase 13
MGI:1346864


Nomenclature History
Synonyms p38 delta MAP kinase, SAPK4, Serk4
Genetic Map
Chromosome 17
cytoband A3-B
 
Mapping data( 2)
Sequence Map
Chr17:28906252-28915643 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF105100
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024249 VEGA Gene Model | MGI Sequence Detail 9392 C57BL/6J ± Kb
transcript NM_011950 RefSeq | MGI Sequence Detail 1406 -
polypeptide Q9Z1B7 UniProt | EBI | MGI Sequence Detail 366 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(3) Targeted, other(1) Gene trapped(1)
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin secretion, decreased blood glucose, and decreased susceptibility to diet- or chemically-induced diabetes.
Polymorphisms SNPs within 2kb(70 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell cycle, protein amino acid phosphorylation...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (1)    Results (1)    Tissues (1)    Images (1)
Theiler Stages: 19
  Assay Type Assays   Results
      RNA in situ 1   1
cDNA source data(48)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(49) cDNA(49) Antibodies(1)
Microarray probesets(2)
Other database
links
EC 2.7.11.24
Ensembl Gene Model ENSMUSG00000004864
DoTS DT.490228, DT.97389875
Consensus CDS Project CCDS28584.1
UniGene 27970
DFCI TC1581117
Entrez Gene 26415
VEGA Gene Model OTTMUSG00000024249
International Mouse Knockout Project Status Mapk13
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR003527 MAP kinase, conserved site
IPR008352 MAP kinase, p38
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:38682 Foltz IN et al., "Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway." J Biol Chem 1997 Feb 7;272(6):3296-301
(Latest) J:149440 Schindler EM et al., "p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice." Cancer Res 2009 Jun 1;69(11):4648-55
All references(13)
Other
accession IDs
MGI:1195258

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory