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Aplnr Gene Detail
 Symbol
Name
ID
Aplnr
apelin receptor
MGI:1346086

Nomenclature History
Synonyms Agtrl1, apelin receptor, APJ, msr/apj
Genetic Map
Chromosome 2
cytoband E1
 
Mapping data( 3)
Sequence Map
Chr2:84976557-84980080 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: apelin receptor
TreeFam: TF330024
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000013465 VEGA Gene Model | MGI Sequence Detail 3524 C57BL/6J ± Kb
transcript NM_011784 RefSeq | MGI Sequence Detail 3573 C57BL/6
polypeptide Q9WV08 UniProt | EBI | MGI Sequence Detail 377 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(3)
Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance.
Polymorphisms SNPs within 2kb(47 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process G-protein coupled receptor protein signaling pathway, signal transduction...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, receptor activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (3)    Results (60)    Tissues (50)    Images (16)
Theiler Stages: 11,12,13,14,15,17,19
  Assay Type Assays   Results
      RNA in situ 3   60
cDNA source data(39)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(41) cDNA(41)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000044338
DoTS DT.101228518, DT.91294039, DT.97375808
Consensus CDS Project CCDS16201.1
UniGene 29368
DFCI TC1576841
NIA Mouse Gene Index U002007
Entrez Gene 23796
VEGA Gene Model OTTMUSG00000013465
International Mouse Knockout Project Status Aplnr
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR003904 APJ receptor
IPR017452 GPCR, rhodopsin-like superfamily
IPR020279 Apelin receptor, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:56817 Devic E et al., "Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ." Mech Dev 1999 Jun;84(1-2):199-203
(Latest) J:154303 Charo DN et al., "Endogenous regulation of cardiovascular function by apelin-APJ." Am J Physiol Heart Circ Physiol 2009 Nov;297(5):H1904-13
All references(14)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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