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Slc11a1 Gene Detail
 Symbol
Name
ID
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275


Nomenclature History
Synonyms Bcg, host resistance locus Bcg/Ity/Lsh, Ity, ity, Lsh, Nramp, Nramp1
Genetic Map
Chromosome 1
39.2 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 64)

Sequence Map
Chr1:74421777-74432636 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc11a1 ± 2 cM)
Protein SuperFamily: divalent metal ion transporter, NRAMP type
TreeFam: TF315185
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016632 VEGA Gene Model | MGI Sequence Detail 10860 C57BL/6J ± Kb
transcript NM_013612 RefSeq | MGI Sequence Detail 2304 C57BL/6
polypeptide P41251 UniProt | EBI | MGI Sequence Detail 548 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Spontaneous(2)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(2) SNPs within 2kb(14 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process activation of protein kinase activity, antigen processing and presentation of peptide antigen...
Component cell outer membrane, endosome membrane...
Function iron ion binding, manganese ion transmembrane transporter activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(22)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(22) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000026177
DoTS DT.101725612, DT.97386549, DT.99843454
Consensus CDS Project CCDS15047.1
UniGene 2913
DFCI TC1583294
NIA Mouse Gene Index U000449
Entrez Gene 18173
VEGA Gene Model OTTMUSG00000016632
International Mouse Knockout Project Status Slc11a1
Protein
domains
InterPro ID Description
IPR001046 Natural resistance-associated macrophage protein
Graphical View of Protein Domain Structure
References
(Earliest) J:24667 Webster LT, "Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding" J Exp Med 1933;57():793-843
(Latest) J:154192 Wong CE et al., "Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction." Infect Immun 2009 Nov;77(11):4750-60
All references(167)
Other
accession IDs
MGD-MRK-11510, MGD-MRK-11511, MGD-MRK-11891, MGD-MRK-1520, MGD-MRK-16714, MGD-MRK-24163, MGI:103283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory