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Lynx1 Gene Detail
 Symbol
Name
ID
Lynx1
Ly6/neurotoxin 1
MGI:1345180

Nomenclature History
Genetic Map
Chromosome 15
Syntenic
 
Mapping data( 2)
Sequence Map
Chr15:74581357-74583405 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Protein SuperFamily: Ly-6-like protein
TreeFam: TF336080
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000022594 Ensembl Gene Model | MGI Sequence Detail 2049 C57BL/6J ± Kb
transcript NM_011838 RefSeq | MGI Sequence Detail 3952 C57BL/6
polypeptide Q9WVC2 UniProt | EBI | MGI Sequence Detail 116 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Gene trapped(1)
Mice homozygous for a null allele exhibit increased sensitivity to nicotine, neurodegeneration, brain vacuoles amd improved cue-conditioned learning.
Polymorphisms SNPs within 2kb(49 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process synaptic transmission, cholinergic
Component anchored to membrane, membrane...
Function acetylcholine receptor inhibitor activity, ion channel inhibitor activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (93)    Tissues (93)    Images (13)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   93
cDNA source data(25)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022594
DoTS DT.101372046, DT.483952
Consensus CDS Project CCDS27530.1
UniGene 257067
DFCI TC1578896, TC1602662
NIA Mouse Gene Index U191082
Entrez Gene 23936
International Mouse Knockout Project Status Lynx1
Protein
domains
InterPro ID Description
IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like
Graphical View of Protein Domain Structure
References
(Earliest) J:55427 Miwa JM et al., "lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS." Neuron 1999 May;23(1):105-14
(Latest) J:122965 Miwa JM et al., "The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo." Neuron 2006 Sep 7;51(5):587-600
All references(9)
Other
accession IDs 		MGI:2146067
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory