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Pglyrp1 Gene Detail
 Symbol
Name
ID
Pglyrp1
peptidoglycan recognition protein 1
MGI:1345092

Nomenclature History
Synonyms peptidoglycan recognition protein, PGRP-S, Tag7, Tasg7, Tnfsf3l
Genetic Map
Chromosome 7
cytoband A3
 
Mapping data( 2)
Sequence Map
Chr7:19470057-19475787 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: peptidoglycan recognition protein, PGRP-S type
TreeFam: TF323898
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000030413 Ensembl Gene Model | MGI Sequence Detail 5731 C57BL/6J ± Kb
transcript NM_009402 RefSeq | MGI Sequence Detail 681 C57BL/6
polypeptide O88593 UniProt | EBI | MGI Sequence Detail 182 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous mutant mice show a defect in neutrophil killing and increased susceptibility to infection with non-pathogenic gram-positive bacteria.
Polymorphisms SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process apoptosis, defense response to bacterium...
Component cytoplasm, extracellular region...
Function cytokine activity, N-acetylmuramoyl-L-alanine amidase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(51)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(53) Genomic(1) cDNA(51) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030413
DoTS DT.491985, DT.91393161
Consensus CDS Project CCDS20881.1
UniGene 21855
DFCI TC1581549, TC1634378
NIA Mouse Gene Index U007745
Entrez Gene 21946
International Mouse Knockout Project Status Pglyrp1
Protein
domains
InterPro ID Description
IPR002502 N-acetylmuramoyl-L-alanine amidase, family 2
IPR006619 Peptidoglycan recognition protein, metazoa/bacteria
IPR015510 Peptidoglycan recognition protein
IPR017331 Peptidoglycan recognition protein, PGRP-S
Graphical View of Protein Domain Structure
References
(Earliest) J:33630 Kustikova OS et al., "[Cloning of the tag7 gene expressed in metastatic mouse tumors]" Genetika 1996 May;32(5):621-8
(Latest) J:154554 Ghosh A et al., "A novel antimicrobial peptidoglycan recognition protein in the cornea." Invest Ophthalmol Vis Sci 2009 Sep;50(9):4185-91
All references(11)
Other
accession IDs 		MGD-MRK-35884, MGI:107415, MGI:1306810
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory