About   Help   FAQ
Tour our new Quick Search
Scnm1 Gene Detail
 Symbol
Name
ID
Scnm1
sodium channel modifier 1
MGI:1341284

Nomenclature History
Synonyms 3110001I17Rik
Genetic Map
Chromosome 3
49.7 cM, cytoband F2
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr3:94933458-94938420 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Scnm1 ± 2 cM)
TreeFam: TF332168
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022306 VEGA Gene Model | MGI Sequence Detail 4963 C57BL/6J ± Kb
transcript NM_027013 RefSeq | MGI Sequence Detail 888 C57BL/6
polypeptide Q8K136 UniProt | EBI | MGI Sequence Detail 229 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes 		All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(6) Spontaneous(1) Chemically induced(1)
The Scnm1 locus influences the severity of the Scn8a phenotype. Mice carrying the recesive susceptibility allele of the modifier are paralyzed and do not survive beyond 1 month. Mice carryimg the resistant wildtype allele display progressive dystonia with ataxia and live more than 1.5 years.
Polymorphisms SNPs within 2kb(44 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process mRNA processing, RNA splicing...
Component nucleus
Function metal ion binding, zinc ion binding...
External Resources: FuncBase
Expression cDNA source data(71)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(71) cDNA(71)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000005629
UniGene 182944
DFCI TC1579012, TC1631205
NIA Mouse Gene Index U024353
Entrez Gene 69269
VEGA Gene Model OTTMUSG00000022306
International Mouse Knockout Project Status Scnm1
References
(Earliest) J:53340 Sprunger LK et al., "Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3." Hum Mol Genet 1999 Mar;8(3):471-9
(Latest) J:141236 Howell VM et al., "A Targeted Deleterious Allele of the Splicing Factor SCNM1 in the Mouse." Genetics 2008 Nov;180(3):1419-27
All references(10)
Other
accession IDs 		MGI:1916519
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory