Symbol
Name
ID
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Synonyms
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CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSFR
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(63)
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Alleles
and
phenotypes
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All alleles(2) :
Targeted, knock-out(1)
Targeted, other(1)
| Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia. |
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Polymorphisms
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RFLP(10)
SNPs within 2kb(127 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (27 records)
Data Summary:
Assays (14)
Results (110)
Tissues (68)
Images (2)
Theiler Stages: 4,10,11,12,13,14,15,17,18,19,20,21,23,24,25,26,28
| |
Assay Type |
Assays |
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Results |
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RT-PCR |
9 |
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88 |
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Immunohistochemistry |
2 |
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8 |
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Nuclease S1 |
1 |
|
5 |
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Northern blot |
2 |
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9 |
cDNA source data(99)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(120)
Genomic(8)
cDNA(103)
Primer pair(6)
Other(3)
Antibodies(1)
Microarray probesets(4)
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Other database
links
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| EC |
2.7.10.1 |
| Ensembl Gene Model |
ENSMUSG00000024621 |
| DoTS |
DT.101139906, DT.101163850, DT.101406752, DT.101406754, DT.110764711, DT.491839, DT.55147791, DT.97364722, DT.97364723 |
| Consensus CDS Project |
CCDS29280.1 |
| UniGene |
22574 |
| PDB |
3EJJ |
| DFCI |
TC1573741, TC1607361, TC1637006, TC1687081, TC1695820 |
| Entrez Gene |
12978 |
| VEGA Gene Model |
OTTMUSG00000014918 |
| International Mouse Knockout Project Status |
Csf1r |
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Protein
domains
|
| InterPro ID |
Description |
| IPR000601 |
PKD |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR001824 |
Tyrosine-protein kinase, receptor class III, conserved site |
| IPR003598 |
Immunoglobulin subtype 2 |
| IPR003599 |
Immunoglobulin subtype |
| IPR007110 |
Immunoglobulin-like |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR013098 |
Immunoglobulin I-set |
| IPR013783 |
Immunoglobulin-like fold |
| IPR016243 |
Tyrosine-protein kinase, CSF-1/PDGF receptor |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR020635 |
Tyrosine-protein kinase, subgroup, catalytic domain |
| IPR020685 |
Tyrosine-protein kinase |
| IPR020729 |
Tyrosine-protein kinase, macrophage colony-stimulating factor 1 receptor |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:6867
Muller R et al.,
"Differential expression of cellular oncogenes during pre- and postnatal development of the mouse."
Nature 1982 Oct 14;299(5884):640-4
(Latest)
J:155668
Ginhoux F et al.,
"The origin and development of nonlymphoid tissue CD103+ DCs."
J Exp Med 2009 Dec 21;206(13):3115-30
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All references(95)
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Other
accession IDs
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MGD-MRK-2192, MGD-MRK-9798, MGD-MRK-9845, MGI:2147208, MGI:88535
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Analysis Tools
MGI BioMart
