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S1pr3 Gene Detail
 Symbol
Name
ID
S1pr3
sphingosine-1-phosphate receptor 3
MGI:1339365


Nomenclature History
Synonyms Edg3, LPb3, S1P3
Genetic Map
Chromosome 13
cytoband B1
 
Mapping data( 3)
Sequence Map
Chr13:51504133-51518166 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
TreeFam: TF330052
Sequences
Representative Sequences Length Strain/Species Flank
genomic 13610 NCBI Gene Model | MGI Sequence Detail 14034 C57BL/6J ± Kb
transcript NM_010101 RefSeq | MGI Sequence Detail 4484 C57BL/6
polypeptide Q9Z0U9 UniProt | EBI | MGI Sequence Detail 378 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(3)
Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.
Phenotype Images (5)  
Polymorphisms SNPs within 2kb(139 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cytokine production, G-protein coupled receptor protein signaling pathway...
Component integral to membrane, integral to plasma membrane...
Function G-protein coupled receptor activity, lysosphingolipid and lysophosphatidic acid receptor activity...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Assays (4)    Results (15)    Tissues (15)    Images (4)
Theiler Stages: 11,13,15,17,19,20,22
  Assay Type Assays   Results
      RT-PCR 2   13
      RNA in situ 2   2
cDNA source data(61)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(64) cDNA(62) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000067586
DoTS DT.101320544
Consensus CDS Project CCDS26512.1
UniGene 136736
DFCI TC1572407
NIA Mouse Gene Index U014842
Entrez Gene 13610
International Mouse Knockout Project Status S1pr3
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR004061 Sphingosine 1-phosphate receptor
IPR004062 EDG-3 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:52870 Zhang G et al., "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate." Gene 1999 Feb 4;227(1):89-99
(Latest) J:148410 Combes AN et al., "Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development." Dev Dyn 2009 May;238(5):1033-41
All references(34)
Other
accession IDs
MGI:2145186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory