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Bmpr1a Gene Detail
 Symbol
Name
ID
Bmpr1a
bone morphogenetic protein receptor, type 1A
MGI:1338938

Nomenclature History
Synonyms 1110037I22Rik, ALK3, Bmpr, BMPR-IA
Genetic Map
Chromosome 14
13.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr14:35224255-35315732 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Bmpr1a ± 2 cM)
Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
TreeFam: TF314724
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000021796 Ensembl Gene Model | MGI Sequence Detail 91478 C57BL/6J ± Kb
transcript NM_009758 RefSeq | MGI Sequence Detail 5481 C57BL/6
polypeptide P36895 UniProt | EBI | MGI Sequence Detail 532 Not Applicable
For the selected sequences
All sequences(42)
Alleles
and
phenotypes 		All alleles(61) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(57)
Homozygous null mutants die by embryonic dat 9.5, are smaller than normal, and form no mesoderm; a conditional knockout resulted in gross malformations of the limbs with complete agenesis of the hindlimb.
Associated Human Diseases (3)   Alleles Annotated to Human Diseases (3)   Phenotype Images (6)  
Polymorphisms RFLP(1) SNPs within 2kb(434 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process anterior/posterior pattern formation, BMP signaling pathway...
Component integral to membrane, membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (61 records)
Data Summary: Assays (10)    Results (121)    Tissues (115)    Images (28)
Theiler Stages: 14,15,18,19,20,21,22,23,24,25,28
  Assay Type Assays   Results
      RT-PCR 3   9
      RNA in situ 7   112
cDNA source data(151)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(159) Genomic(1) cDNA(153) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
EC 2.7.11.30
Ensembl Gene Model ENSMUSG00000021796
DoTS DT.91447630, DT.91447662, DT.97358438
Consensus CDS Project CCDS26938.1
UniGene 237825
DFCI TC1582055, TC1589489, TC1631543, TC1649499, TC1669064
NIA Mouse Gene Index U035410
Entrez Gene 12166
International Mouse Knockout Project Status Bmpr1a
Protein
domains
InterPro ID Description
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:1022 Gorecki D et al., "Expression of the dystrophin gene in mouse and rat brain." Neuroreport 1991 Dec;2(12):773-6
(Latest) J:156015 Blitz E et al., "Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction." Dev Cell 2009 Dec;17(6):861-73
All references(133)
Other
accession IDs 		MGD-MRK-1605, MGI:1915998, MGI:2145761, MGI:88183
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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