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Btrc Gene Detail
 Symbol
Name
ID
Btrc
beta-transducin repeat containing protein
MGI:1338871

Nomenclature History
Synonyms beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
Genetic Map
Chromosome 19
cytoband D1
 
Mapping data( 2)
Sequence Map
Chr19:45438235-45604503 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF105679
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 166269 C57BL/6J ± Kb
transcript NM_001037758 RefSeq | MGI Sequence Detail 6358 C57BL/6
polypeptide NP_001032847 RefSeq | MGI Sequence Detail 605 C57BL/6
For the selected sequences
All sequences(74)
Alleles
and
phenotypes 		All alleles(16) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(12)
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
Polymorphisms SNPs within 2kb(787 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process branching involved in mammary gland duct morphogenesis, mammary gland epithelial cell proliferation...
Function ligase activity, protein binding...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (1)    Results (94)    Tissues (94)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   94
cDNA source data(17)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025217
DoTS DT.101212313, DT.101366784, DT.101368656, DT.40183134, DT.532668, DT.97340153, DT.97372748, DT.97398503, DT.97407422, DT.99851622, DT.99861261, DT.99861271
Consensus CDS Project CCDS29860.1, CCDS38002.1
DFCI TC1574058, TC1602429, TC1613015, TC1630975, TC1631878, TC1676033, TC1690259
NIA Mouse Gene Index U019505
Entrez Gene 12234
International Mouse Knockout Project Status Btrc
Protein
domains
InterPro ID Description
IPR001680 WD40 repeat
IPR001810 Cyclin-like F-box
IPR011046 WD40 repeat-like-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR017986 WD40-repeat-containing domain
IPR019775 WD40 repeat, conserved site
IPR019781 WD40 repeat, subgroup
IPR019782 WD40 repeat 2
IPR020472 G-protein beta WD-40 repeat, region
References
(Earliest) J:54317 Yaron A et al., "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." Nature 1998 Dec 10;396(6711):590-4
(Latest) J:152698 Baguma-Nibasheka M et al., "Abnormal retinal development in the Btrc null mouse." Dev Dyn 2009 Aug 24;238(10):2680-2687
All references(27)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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