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Pstpip2 Gene Detail
 Symbol
Name
ID
Pstpip2
proline-serine-threonine phosphatase-interacting protein 2
MGI:1335088

Nomenclature History
Synonyms cmo
Genetic Map
Chromosome 18
45.0 cM, cytoband E3
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr18:78033289-78121618 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pstpip2 ± 2 cM)
TreeFam: TF313677
Sequences
Representative Sequences Length Strain/Species Flank
genomic 19201 NCBI Gene Model | MGI Sequence Detail 88330 C57BL/6J ± Kb
transcript NM_013831 RefSeq | MGI Sequence Detail 3138 C57BL/6
polypeptide Q99M15 UniProt | EBI | MGI Sequence Detail 334 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(5) : Gene trapped(3) Spontaneous(1) Chemically induced(1)
Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(497 from dbSNP Build 128)   SNPs within 2kb including multiple locations(499)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cytoskeleton organization
Component cytoplasm, cytoskeleton...
Function actin binding
External Resources: FuncBase
Expression cDNA source data(28)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(28) cDNA(28)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025429
DoTS DT.101301109, DT.101703568, DT.110761213, DT.529907, DT.55113285, DT.94175632, DT.94175633
Consensus CDS Project CCDS37868.1
UniGene 57174
DFCI TC1582111, TC1591855, TC1614253, TC1614836
NIA Mouse Gene Index U018920
Entrez Gene 19201
International Mouse Knockout Project Status Pstpip2
Protein
domains
InterPro ID Description
IPR001060 Fps/Fes/Fer/CIP4 homology
Graphical View of Protein Domain Structure
References
(Earliest) J:1534 Byrd L et al., "Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse." Genomics 1991 Dec;11(4):794-8
(Latest) J:152809 Chitu V et al., "Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice." Blood 2009 Sep 17;114(12):2497-505
All references(12)
Other
accession IDs 		MGD-MRK-2028, MGI:88427
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory