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Cldn1 Gene Detail
 Symbol
Name
ID
Cldn1
claudin 1
MGI:1276109


Nomenclature History
Genetic Map
Chromosome 16
Syntenic
 
Mapping data( 2)
Sequence Map
Chr16:26356728-26371927 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF331936
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022624 VEGA Gene Model | MGI Sequence Detail 15200 C57BL/6J ± Kb
transcript NM_016674 RefSeq | MGI Sequence Detail 3236 C57BL/6
polypeptide O88551 UniProt | EBI | MGI Sequence Detail 211 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Animals homozygous for a mutation in this gene have wrinkled skin and die within 1 day after birth.
Phenotype Images (4)  
Polymorphisms SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process calcium-independent cell-cell adhesion
Component cell junction, integral to membrane...
Function identical protein binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Assays (6)    Results (20)    Tissues (15)    Images (6)
Theiler Stages: 20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 2   2
      RT-PCR 2   6
      Immunohistochemistry 2   12
cDNA source data(71)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(73) cDNA(71) Primer pair(2) Antibodies(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022512
DoTS DT.101739680, DT.97363823
Consensus CDS Project CCDS28087.1
UniGene 289441
DFCI TC1575234
NIA Mouse Gene Index U036934
Entrez Gene 12737
VEGA Gene Model OTTMUSG00000022624
International Mouse Knockout Project Status Cldn1
Protein
domains
InterPro ID Description
IPR003548 Claudin-1
IPR004031 PMP-22/EMP/MP20/Claudin
IPR006187 Claudin
IPR017974 Claudin, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:48635 Furuse M et al., "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin." J Cell Biol 1998 Jun 29;141(7):1539-50
(Latest) J:144091 Tinkle CL et al., "New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity." Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15405-10
All references(30)
Other
accession IDs
MGI:2146462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory