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Socs3 Gene Detail
 Symbol
Name
ID
Socs3
suppressor of cytokine signaling 3
MGI:1201791

Nomenclature History
Synonyms CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3
Genetic Map
Chromosome 11
cytoband E2
 
Mapping data( 2)
Sequence Map
Chr11:117827393-117831361 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: suppressor of cytokine signaling (SOCS) 1-3
TreeFam: TF321368
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003735 VEGA Gene Model | MGI Sequence Detail 3969 C57BL/6J ± Kb
transcript NM_007707 RefSeq | MGI Sequence Detail 2742 C57BL/6
polypeptide O35718 UniProt | EBI | MGI Sequence Detail 225 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(16) : Targeted, knock-out(4) Targeted, other(4) Gene trapped(8)
Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.
Polymorphisms SNPs within 2kb(1 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process branching involved in embryonic placenta morphogenesis, intracellular signaling cascade...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (2)    Results (12)    Tissues (12)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      Northern blot 2   12
cDNA source data(51)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000053113
DoTS DT.101221192, DT.530948
Consensus CDS Project CCDS25697.1
UniGene 3468
PDB 2BBU, 2HMH, 2JZ3
DFCI TC1571892
NIA Mouse Gene Index U033671
Entrez Gene 12702
VEGA Gene Model OTTMUSG00000003735
International Mouse Knockout Project Status Socs3
Protein
domains
InterPro ID Description
IPR000980 SH2 motif
IPR001496 SOCS protein, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:42258 Minamoto S et al., "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." Biochem Biophys Res Commun 1997 Aug 8;237(1):79-83
(Latest) J:155741 Smith PD et al., "SOCS3 deletion promotes optic nerve regeneration in vivo." Neuron 2009 Dec 10;64(5):617-23
All references(91)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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