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Klrk1 Gene Detail
 Symbol
Name
ID
Klrk1
killer cell lectin-like receptor subfamily K, member 1
MGI:1196250

Nomenclature History
Synonyms D6H12S2489E, NKG2-D, Nkg2d
Genetic Map
Chromosome 6
62.53 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr6:129560341-129573882 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Klrk1 ± 2 cM)
TreeFam: TF336674
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000032505 VEGA Gene Model | MGI Sequence Detail 13542 C57BL/6J ± Kb
transcript NM_033078 RefSeq | MGI Sequence Detail 3262 C57BL/6
polypeptide O54709 UniProt | EBI | MGI Sequence Detail 232 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(2)
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(121 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process natural killer cell activation, positive regulation of interferon-gamma production...
Component external side of plasma membrane, integral to membrane...
Function binding, MHC class I protein binding...
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(15)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(20) Genomic(4) cDNA(15) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030149
DoTS DT.101346781, DT.110480895, DT.87072035, DT.87072157
Consensus CDS Project CCDS39660.1, CCDS39661.1
UniGene 8217
PDB 1HQ8, 1JSK
DFCI TC1588467, TC1654782
NIA Mouse Gene Index U027920
Entrez Gene 27007
VEGA Gene Model OTTMUSG00000032505
International Mouse Knockout Project Status Klrk1
Protein
domains
InterPro ID Description
IPR001304 C-type lectin
IPR002353 Type II antifreeze protein
IPR016186 C-type lectin-like
IPR016187 C-type lectin fold
Graphical View of Protein Domain Structure
References
(Earliest) J:45141 Vance RE et al., "Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells." Eur J Immunol 1997 Dec;27(12):3236-41
(Latest) J:151878 Zafirova B et al., "Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice." Immunity 2009 Aug 21;31(2):270-82
All references(40)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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