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Lims1 Gene Detail
 Symbol
Name
ID
Lims1
LIM and senescent cell antigen-like domains 1
MGI:1195263


Nomenclature History
Synonyms 2310016J22Rik, 4921524A02Rik, C430041B13Rik, Lims1l, PINCH1
Genetic Map
Chromosome 10
30.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr10:57786214-57887439 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Lims1 ± 2 cM)
Protein SuperFamily: PINCH protein
TreeFam: TF314113
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024823 VEGA Gene Model | MGI Sequence Detail 101226 C57BL/6J ± Kb
transcript NM_026148 RefSeq | MGI Sequence Detail 4244 C57BL/6
polypeptide Q99JW4 UniProt | EBI | MGI Sequence Detail 325 Not Applicable
For the selected sequences
All sequences(47)
Alleles
and
phenotypes
All alleles(46) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(41)
Homozygous null mice die shortly after implantation and have a disorganized egg cylinder by E5.5, which is degenerated by E6.5. E5.5 null embryos exhibit decreased cell proliferation and excessive cell death.
Polymorphisms PCR(1) SNPs within 2kb(218 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell-cell adhesion, cell-matrix adhesion...
Component cell junction, focal adhesion...
Function metal ion binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (8)    Results (73)    Tissues (50)    Images (5)
Theiler Stages: 2,3,4,5,7,9,11,17,21,28
  Assay Type Assays   Results
      Western blot 1   2
      RT-PCR 2   18
      RNA in situ 4   51
      Immunohistochemistry 1   2
cDNA source data(23)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(3) Antibodies(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000019920
DoTS DT.101387792, DT.110605481, DT.87072540, DT.91329704, DT.94222883
Consensus CDS Project CCDS23860.1
DFCI TC1576181, TC1587266, TC1591811, TC1599645, TC1601054, TC1699293
NIA Mouse Gene Index U043076
Entrez Gene 110829
VEGA Gene Model OTTMUSG00000024823
International Mouse Knockout Project Status Lims1
Protein
domains
InterPro ID Description
IPR001781 Zinc finger, LIM-type
IPR017351 PINCH
Graphical View of Protein Domain Structure
References
(Earliest) J:44723 Rearden A, "A new LIM protein containing an autoepitope homologous to senescent cell antigen." Biochem Biophys Res Commun 1994 Jun 30;201(3):1124-31
(Latest) J:154054 Lange A et al., "Integrin-linked kinase is an adaptor with essential functions during mouse development." Nature 2009 Oct 15;461(7266):1002-6
All references(22)
Other
accession IDs
MGI:1914678, MGI:1919149, MGI:2143635, MGI:2143741, MGI:2143862, MGI:2445157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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