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Bmx Gene Detail
 Symbol
Name
ID
Bmx
BMX non-receptor tyrosine kinase
MGI:1101778

Nomenclature History
Synonyms Etk, Etk/Bmx, Tyro8
Genetic Map
Chromosome X
cytoband F
 
Mapping data( 3)
Sequence Map
ChrX:160630774-160696125 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: tyrosine-protein kinase, TEC type
TreeFam: TF315363
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000019502 VEGA Gene Model | MGI Sequence Detail 65352 C57BL/6J ± Kb
transcript NM_009759 RefSeq | MGI Sequence Detail 3005 C57BL/6
polypeptide P97504 UniProt | EBI | MGI Sequence Detail 651 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes 		All alleles(2) : Targeted, other(1) Gene trapped(1)
Mice homozygous for a null mutation are fertile and have a normal life span.
Polymorphisms SNPs within 2kb(209 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process intracellular signaling cascade, protein amino acid phosphorylation...
Component cytoplasm
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (4)    Results (43)    Tissues (29)
Theiler Stages: 9,15,17,20,23,26,28
  Assay Type Assays   Results
      RT-PCR 3   38
      Northern blot 1   5
cDNA source data(16)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(20) Genomic(2) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
EC 2.7.10.2
Ensembl Gene Model ENSMUSG00000031377
DoTS DT.101723582
Consensus CDS Project CCDS30519.1
UniGene 504
DFCI TC1587485
NIA Mouse Gene Index U039857
Entrez Gene 12169
VEGA Gene Model OTTMUSG00000019502
International Mouse Knockout Project Status Bmx
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000980 SH2 motif
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology
IPR008266 Tyrosine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR011993 Pleckstrin homology-type
IPR017441 Protein kinase, ATP binding site
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020685 Tyrosine-protein kinase
Graphical View of Protein Domain Structure
References
(Earliest) J:36874 Rinke de Wit TF et al., "Expression of tyrosine kinase gene in mouse thymic stromal cells." Int Immunol 1996 Nov;8(11):1787-95
(Latest) J:155268 Mitchell-Jordan SA et al., "Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy." Circ Res 2008 Dec 5;103(12):1359-62
All references(11)
Other
accession IDs 		MGD-MRK-38318, MGI:109273
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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