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Ltbp3 Gene Detail
 Symbol
Name
ID
Ltbp3
latent transforming growth factor beta binding protein 3
MGI:1101355

Nomenclature History
Synonyms Ltbp2
Genetic Map
Chromosome 19
2.0 cM, cytoband B
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr19:5740904-5758532 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ltbp3 ± 2 cM)
TreeFam: TF317514
Sequences
Representative Sequences Length Strain/Species Flank
genomic 16998 NCBI Gene Model | MGI Sequence Detail 17629 C57BL/6J ± Kb
transcript NM_008520 RefSeq | MGI Sequence Detail 5209 C57BL/6
polypeptide Q61810 UniProt | EBI | MGI Sequence Detail 1268 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes 		All alleles(5) : Targeted, knock-out(1) Gene trapped(3) Chemically induced(1)
Homozygotes for a targeted null mutation exhibit craniofacial malformations including an overshot mandible and ossification of synchondroses. Mutants develop osteosclerosis of long bones and osteoarthritis, and, in some cases, high corticosterone levels.
Phenotype Images (4)  
Polymorphisms SNPs within 2kb(55 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process skeletal system development, transforming growth factor beta receptor signaling pathway...
Component extracellular region, proteinaceous extracellular matrix...
Function binding, calcium ion binding...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (1)    Results (61)    Tissues (61)    Images (13)
Theiler Stages: 14,21,24,28
  Assay Type Assays   Results
      RNA in situ 1   61
cDNA source data(122)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(132) Genomic(2) cDNA(125) Primer pair(3) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024940
Consensus CDS Project CCDS37891.1
UniGene 182396
DFCI TC1576285, TC1598025
NIA Mouse Gene Index U038709
Entrez Gene 16998
International Mouse Knockout Project Status Ltbp3
Protein
domains
InterPro ID Description
IPR000152 EGF-type aspartate/asparagine hydroxylation site
IPR000742 EGF-like, type 3
IPR001881 EGF-like calcium-binding
IPR002212 Matrix fibril-associated
IPR006210 EGF-like
IPR013032 EGF-like region, conserved site
IPR013091 EGF calcium-binding
IPR017878 TGF-beta binding
IPR018097 EGF-like calcium-binding, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:22443 Li X et al., "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)." Mamm Genome 1995 Jan;6(1):42-5
(Latest) J:128012 Todorovic V et al., "Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling." Development 2007 Oct;134(20):3723-32
All references(22)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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