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Chl1 Gene Detail
 Symbol
Name
ID
Chl1
cell adhesion molecule with homology to L1CAM
MGI:1098266


Nomenclature History
Synonyms A530023M13Rik, CALL, close homolog of L1, LICAM2
Genetic Map
Chromosome 6
cytoband E1
 
Mapping data( 3)
Sequence Map
Chr6:103460870-103683029 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic    (Mammalian Orthology)
Protein SuperFamily: neural cell adhesion molecule-like protein
TreeFam: TF321796
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12661 NCBI Gene Model | MGI Sequence Detail 222160 C57BL/6J ± Kb
transcript NM_007697 RefSeq | MGI Sequence Detail 7751 C57BL/6
polypeptide P70232 UniProt | EBI | MGI Sequence Detail 1209 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.
Polymorphisms SNPs within 2kb(1437 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process adult locomotory behavior, axon guidance...
Component apical part of cell, dendrite...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (3)    Results (33)    Tissues (21)
Theiler Stages: 18,21,22,26,28
  Assay Type Assays   Results
      Western blot 2   10
      RNA in situ 1   23
cDNA source data(72)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(72) cDNA(72) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030077
DoTS DT.101187375, DT.101300318, DT.522149, DT.91384136, DT.94187408, DT.94187413, DT.97389158
Consensus CDS Project CCDS39582.1
UniGene 251288
DFCI TC1580155, TC1591428, TC1609863, TC1634954, TC1652011, TC1746648
NIA Mouse Gene Index U007238
Entrez Gene 12661
International Mouse Knockout Project Status Chl1
Protein
domains
InterPro ID Description
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like
IPR008957 Fibronectin, type III-like fold
IPR013098 Immunoglobulin I-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:36169 Holm J et al., "Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules." Eur J Neurosci 1996 Aug;8(8):1613-29
(Latest) J:154369 Lanier J et al., "Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion." Dev Dyn 2009 Oct 29;238(12):3065-3079
All references(24)
Other
accession IDs
MGI:2141424, MGI:2442516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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