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St6gal1 Gene Detail
 Symbol
Name
ID
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
MGI:108470


Nomenclature History
Synonyms Siat1, ST6Gal I, St6Gal-I
Genetic Map
Chromosome 16
15.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr16:23224813-23360421 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human St6gal1 ± 2 cM)
Protein SuperFamily: sialyltransferase
TreeFam: TF323961
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000025920 VEGA Gene Model | MGI Sequence Detail 135609 C57BL/6J ± Kb
transcript NM_145933 RefSeq | MGI Sequence Detail 4529 C57BL/6
polypeptide Q64685 UniProt | EBI | MGI Sequence Detail 403 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(26) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(23)
Homozygous mutation of this gene results in altered terminal glycosylation.
Polymorphisms RFLP(2) SNPs within 2kb(519 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process protein amino acid glycosylation
Component extracellular region, Golgi apparatus...
Function beta-galactoside alpha-2,6-sialyltransferase activity, sialyltransferase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (2)    Results (25)    Tissues (18)
Theiler Stages: 10,12,18,23,25,28
  Assay Type Assays   Results
      RT-PCR 2   25
cDNA source data(136)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(139) Genomic(2) cDNA(136) Primer pair(1)
Microarray probesets(3)
Other database
links
EC 2.4.99.1
Ensembl Gene Model ENSMUSG00000022885
DoTS DT.101385066, DT.102541339, DT.488235
Consensus CDS Project CCDS28077.1
UniGene 149029
DFCI TC1575344
Entrez Gene 20440
VEGA Gene Model OTTMUSG00000025920
International Mouse Knockout Project Status St6gal1
Protein
domains
InterPro ID Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
Graphical View of Protein Domain Structure
References
(Earliest) J:43576 Hamamoto T et al., "Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA." Bioorg Med Chem 1993 Aug;1(2):141-5
(Latest) J:147737 Zeng J et al., "The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice." J Immunol 2009 Apr 15;182(8):4721-7
All references(24)
Other
accession IDs
MGD-MRK-37514, MGI:2146670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory