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Ppap2a Gene Detail
 Symbol
Name
ID
Ppap2a
phosphatidic acid phosphatase type 2A
MGI:108412


Nomenclature History
Synonyms Hpic53, Lipid phosphate phosphatase 1, LPP-1, LPP1, mPAP
Genetic Map
Chromosome 13
cytoband D2.2
 
Mapping data( 1)
Sequence Map
Chr13:113591000-113657888 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: lipid phosphate phosphatase
TreeFam: TF316040
Sequences
Representative Sequences Length Strain/Species Flank
genomic 19012 NCBI Gene Model | MGI Sequence Detail 66889 C57BL/6J ± Kb
transcript NM_008247 RefSeq | MGI Sequence Detail 1414 -
polypeptide Q61469 UniProt | EBI | MGI Sequence Detail 283 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes
All alleles(33) : Gene trapped(33)
Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid.
Polymorphisms SNPs within 2kb(340 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ceramide metabolic process, diacylglycerol biosynthetic process...
Component integral to membrane, integral to plasma membrane...
Function catalytic activity, hydrolase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (93)    Tissues (93)    Images (14)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   93
cDNA source data(45)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(4)
Pathways
triacylglycerol biosynthesis
Other database
links
EC 3.1.3.4
Ensembl Gene Model ENSMUSG00000021759
DoTS DT.101386953, DT.101388811, DT.101705311
Consensus CDS Project CCDS26776.1, CCDS26777.1
UniGene 317186
DFCI TC1575311, TC1585968, TC1775932
NIA Mouse Gene Index U015256
Entrez Gene 19012
International Mouse Knockout Project Status Ppap2a
Protein
domains
InterPro ID Description
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Graphical View of Protein Domain Structure
References
(Earliest) J:28807 Egawa K et al., "Isolation of a novel ras-recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3-E1." FEBS Lett 1995 Sep 18;372(1):74-7
(Latest) J:149782 Tomsig JL et al., "Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo." Biochem J 2009 May 1;419(3):611-8
All references(11)
Other
accession IDs
MGD-MRK-26084, MGD-MRK-37455, MGI:104646

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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