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Prkg1 Gene Detail
 Symbol
Name
ID
Prkg1
protein kinase, cGMP-dependent, type I
MGI:108174

Nomenclature History
Synonyms Prkg1b, Prkgr1b
Genetic Map
Chromosome 19
cytoband C2
 
Mapping data( 3)
Sequence Map
Chr19:30642041-31839312 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee    (Mammalian Orthology)
Protein SuperFamily: cGMP-dependent protein kinase
TreeFam: TF313261
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000052920 Ensembl Gene Model | MGI Sequence Detail 1197272 C57BL/6J ± Kb
transcript NM_001013833 RefSeq | MGI Sequence Detail 3914 C57BL/6
polypeptide Q9Z0Z0 UniProt | EBI | MGI Sequence Detail 686 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes 		All alleles(14) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(9)
Mutant mice exhibit defects associated with disrupted NO/cGMP signalling, including abnormal smooth muscle function (peristalsis and heart contractility) and penile erectile deficiency. Conditional disruption in the hippocampus results in impaired LTP.
Polymorphisms SNPs within 2kb(5318 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process dendrite development, forebrain development...
Component Golgi apparatus
Function ATP binding, cGMP binding...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (4)    Results (12)    Tissues (6)    Images (2)
Theiler Stages: 20,28
  Assay Type Assays   Results
      Western blot 1   7
      RT-PCR 1   2
      RNA in situ 1   1
      Immunohistochemistry 1   2
cDNA source data(7)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(10) cDNA(8) Primer pair(1) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
EC 2.7.11.12
Ensembl Gene Model ENSMUSG00000052920
DoTS DT.50316102, DT.91327255, DT.91575919, DT.94170780, DT.97391296
Consensus CDS Project CCDS29745.1, CCDS29746.1
DFCI TC1586770, TC1590717, TC1612598, TC1613623, TC1616310
NIA Mouse Gene Index U038967
Entrez Gene 19091
International Mouse Knockout Project Status Prkg1
Protein
domains
InterPro ID Description
IPR000595 Cyclic nucleotide-binding
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002290 Serine/threonine-protein kinase domain
IPR002374 cGMP-dependent protein kinase, core
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR014710 RmlC-like jelly roll fold
IPR016232 cGMP-dependant protein kinase
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR018488 Cyclic nucleotide-binding, conserved site
IPR018490 Cyclic nucleotide-binding-like
Graphical View of Protein Domain Structure
References
(Earliest) J:12810 Uhler MD, "Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain." J Biol Chem 1993 Jun 25;268(18):13586-91
(Latest) J:154933 Sawada N et al., "Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels." Mol Cell Biol 2009 Nov;29(22):6018-32
All references(42)
Other
accession IDs 		MGD-MRK-19672, MGD-MRK-37213, MGI:2147712
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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