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Bid Gene Detail
 Symbol
Name
ID
Bid
BH3 interacting domain death agonist
MGI:108093


Nomenclature History
Synonyms 2700049M22Rik
Genetic Map
Chromosome 6
54.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr6:120841948-120866871 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Bid ± 2 cM)
Protein SuperFamily: BH3-interacting domain death agonist
TreeFam: TF102047
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024186 VEGA Gene Model | MGI Sequence Detail 24924 C57BL/6J ± Kb
transcript NM_007544 RefSeq | MGI Sequence Detail 1906 -
polypeptide P70444 UniProt | EBI | MGI Sequence Detail 195 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(39) : Targeted, knock-out(1) Gene trapped(38)
Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(116 from dbSNP Build 128)   SNPs within 2kb including multiple locations(122)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptosis, positive regulation of apoptosis...
Component cytoplasm, cytosol...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Assays (4)    Results (87)    Tissues (55)    Images (1)
Theiler Stages: 10,20,23,26,28
  Assay Type Assays   Results
      Western blot 2   27
      RT-PCR 1   46
      Northern blot 1   14
cDNA source data(50)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(56) Genomic(2) cDNA(52) Primer pair(2) Antibodies(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000004446
DoTS DT.101364674, DT.532380
Consensus CDS Project CCDS20486.1
UniGene 235081
PDB 1DDB, 2VOI
NIA Mouse Gene Index U027813
Entrez Gene 12122
VEGA Gene Model OTTMUSG00000024186
International Mouse Knockout Project Status Bid
Protein
domains
InterPro ID Description
IPR010479 BH3 interacting
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:36730 Wang K et al., "BID: a novel BH3 domain-only death agonist." Genes Dev 1996 Nov 15;10(22):2859-69
(Latest) J:154856 Kim H et al., "Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis." Mol Cell 2009 Nov 13;36(3):487-99
All references(85)
Other
accession IDs
MGD-MRK-37130, MGI:1919829, MGI:2141512, MGI:2141571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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