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Hpgd Gene Detail
 Symbol
Name
ID
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
MGI:108085

Nomenclature History
Synonyms 15-PGDH
Genetic Map
Chromosome 8
cytoband B3.2
 
Mapping data( 4)
Sequence Map
Chr8:58773382-58799002 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: short-chain dehydrogenase
TreeFam: TF324093
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000031613 Ensembl Gene Model | MGI Sequence Detail 25621 C57BL/6J ± Kb
transcript NM_008278 RefSeq | MGI Sequence Detail 1719 C57BL/6
polypeptide Q8VCC1 UniProt | EBI | MGI Sequence Detail 269 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous mutation of this gene results failure of the ductus arteriosus to close and perinatal lethality. Mutant animals die within 12-48 hours after birth due to congestive heart failure. Mice homozygous for a hypomorphic allele exhibit preterm labor.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(274 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process fatty acid metabolic process, lipid metabolic process...
Component cytoplasm
Function 15-hydroxyprostaglandin dehydrogenase (NAD+) activity, binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (2)    Tissues (1)
Theiler Stages: 22
  Assay Type Assays   Results
      RT-PCR 1   2
cDNA source data(61)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(63) cDNA(62) Primer pair(1)
Microarray probesets(3)
Pathways
biosynthesis of prostaglandins
Other database
links
EC 1.1.1.141
Ensembl Gene Model ENSMUSG00000031613
DoTS DT.110869440, DT.493434
Consensus CDS Project CCDS40341.1
UniGene 18832
DFCI TC1576847
NIA Mouse Gene Index U009349
Entrez Gene 15446
International Mouse Knockout Project Status Hpgd
Protein
domains
InterPro ID Description
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:36774 Matsuo M et al., "Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase." Biochim Biophys Acta 1996 Nov 11;1309(1-2):21-4
(Latest) J:150084 Yan M et al., "15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors." Proc Natl Acad Sci U S A 2009 Jun 9;106(23):9409-13
All references(15)
Other
accession IDs 		MGD-MRK-37122, MGI:2142735
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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