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Cav2 Gene Detail
 Symbol
Name
ID
Cav2
caveolin 2
MGI:107571


Nomenclature History
Genetic Map
Chromosome 6
cytoband A2
 
Mapping data( 3)
Sequence Map
Chr6:17231185-17239115 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF315736
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024026 VEGA Gene Model | MGI Sequence Detail 7931 C57BL/6J ± Kb
transcript NM_016900 RefSeq | MGI Sequence Detail 2473 C57BL/6
polypeptide Q9WVC3 UniProt | EBI | MGI Sequence Detail 162 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(2)
Homozygous targeted mutants displayed thickening of lung aveloar septa from proliferation of endothelium and fibrosis, ultimately causing the mice physical limitations. The lung phenotype is the same as that for Cav1 null mutants.
Polymorphisms SNPs within 2kb(116 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process caveola assembly, endocytosis...
Component caveola, cytoplasm...
Function D1 dopamine receptor binding, protein homodimerization activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (4)    Results (9)    Tissues (6)
Theiler Stages: 10,18,23,24,25
  Assay Type Assays   Results
      Western blot 2   3
      Immunohistochemistry 1   2
      Northern blot 1   4
cDNA source data(41)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(42) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000000058
DoTS DT.530405, DT.55246486, DT.97338772
Consensus CDS Project CCDS19923.1
UniGene 396075
DFCI TC1575293, TC1592826
NIA Mouse Gene Index U006563
Entrez Gene 12390
VEGA Gene Model OTTMUSG00000024026
International Mouse Knockout Project Status Cav2
Protein
domains
InterPro ID Description
IPR001612 Caveolin
IPR018361 Caveolin, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:30626 Scherer PE et al., "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family." Proc Natl Acad Sci U S A 1996 Jan 9;93(1):131-5
(Latest) J:149637 Miranda PV et al., "Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm." Biol Reprod 2009 May;80(5):897-904
All references(30)
Other
accession IDs
MGD-MRK-36143, MGI:2141409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory